907 Open Access Asian Australas. J. Anim. Sci. Vol. 27, No. 6 : 907-915 June 2014 http://dx.doi.org/10.5713/ajas.2013.13588
www.ajas.info pISSN 1011-2367 eISSN 1976-5517
Protective Efficacy of Alpha-lipoic Acid against AflatoxinB1-induced Oxidative Damage in the Liver Y. Lia, Q. G. Maa, L. H. Zhao, Y. Q. Guo1, G. X. Duan, J. Y. Zhang, and C. Ji* State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China ABSTRACT: Alpha-lipoic acid (-LA) is not only involved in energy metabolism, but is also a powerful antioxidant that can protect against hepatic oxidative stress induced by some drugs, toxins, or under various physiological and pathophysiological conditions. Here, we investigated the effect of -LA against liver oxidative damage in broilers exposed to aflatoxin B1 (AFB1). Birds were randomly divided into four groups and assigned different diets: basal diet, 300 mg/kg -LA supplementation in basal diet, diet containing 74 g/kg AFB1, and 300 mg/kg -LA supplementation in diet containing 74 g/kg AFB1, for 3 weeks. The results revealed that the addition of 300 mg/kg -LA protected against the liver function damage of broilers induced by chronic low dose of AFB1 as estimated by a significant (p
www.ajas.info pISSN 1011-2367 eISSN 1976-5517
Protective Efficacy of Alpha-lipoic Acid against AflatoxinB1-induced Oxidative Damage in the Liver Y. Lia, Q. G. Maa, L. H. Zhao, Y. Q. Guo1, G. X. Duan, J. Y. Zhang, and C. Ji* State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China ABSTRACT: Alpha-lipoic acid (-LA) is not only involved in energy metabolism, but is also a powerful antioxidant that can protect against hepatic oxidative stress induced by some drugs, toxins, or under various physiological and pathophysiological conditions. Here, we investigated the effect of -LA against liver oxidative damage in broilers exposed to aflatoxin B1 (AFB1). Birds were randomly divided into four groups and assigned different diets: basal diet, 300 mg/kg -LA supplementation in basal diet, diet containing 74 g/kg AFB1, and 300 mg/kg -LA supplementation in diet containing 74 g/kg AFB1, for 3 weeks. The results revealed that the addition of 300 mg/kg -LA protected against the liver function damage of broilers induced by chronic low dose of AFB1 as estimated by a significant (p
