The FASEB Journal • Research Communication
Protective role of macrophage migration inhibitory factor in nonalcoholic steatohepatitis Daniel Heinrichs,*,† Marie-Luise Berres,†,1 Melanie Coeuru,* Meike Knauel,* Andreas Nellen,† Petra Fischer,† Claudia Philippeit,* Richard Bucala,‡ Christian Trautwein,† Hermann E. Wasmuth,†,2 and Jürgen Bernhagen*,3 *Institute of Biochemistry and Molecular Cell Biology and †Department of Internal Medicine III, Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen University, Aachen, Germany; and ‡ Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA MIF is an inflammatory cytokine but is hepatoprotective in models of hepatotoxin-induced liver fibrosis. Hepatic fibrosis can also develop from metabolic liver disease, such as nonalcoholic fatty liver disease (NASH). We investigated the role of MIF in high-fat or methionine- and choline-deficient diet mouse models of NASH. Mifⴚ/ⴚ mice showed elevated liver triglyceride levels (WT, 53ⴞ14 mg/g liver; Mifⴚ/ⴚ, 103ⴞ7 mg/g liver; P
Protective role of macrophage migration inhibitory factor in nonalcoholic steatohepatitis Daniel Heinrichs,*,† Marie-Luise Berres,†,1 Melanie Coeuru,* Meike Knauel,* Andreas Nellen,† Petra Fischer,† Claudia Philippeit,* Richard Bucala,‡ Christian Trautwein,† Hermann E. Wasmuth,†,2 and Jürgen Bernhagen*,3 *Institute of Biochemistry and Molecular Cell Biology and †Department of Internal Medicine III, Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen University, Aachen, Germany; and ‡ Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA MIF is an inflammatory cytokine but is hepatoprotective in models of hepatotoxin-induced liver fibrosis. Hepatic fibrosis can also develop from metabolic liver disease, such as nonalcoholic fatty liver disease (NASH). We investigated the role of MIF in high-fat or methionine- and choline-deficient diet mouse models of NASH. Mifⴚ/ⴚ mice showed elevated liver triglyceride levels (WT, 53ⴞ14 mg/g liver; Mifⴚ/ⴚ, 103ⴞ7 mg/g liver; P
