HHS Public Access Author manuscript Author Manuscript

J Neurol. Author manuscript; available in PMC 2017 March 28. Published in final edited form as: J Neurol. 2016 June ; 263(6): 1146–1155. doi:10.1007/s00415-016-8118-z.

Quantification of normal-appearing white matter tract integrity in multiple sclerosis: a diffusion kurtosis imaging study Ivan de Kouchkovsky, BA1, Els Fieremans, PhD2, Lazar Fleysher, PhD3, Joseph Herbert, MD4, Robert I. Grossman, MD2, and Matilde Inglese, MD, PhD3,5 1Medical

Degree Program, New York University School of Medicine, New York, NY, USA

Author Manuscript

2Department

of Radiology, Neurology (J.H.), New York University School of Medicine, New York,

NY, USA 3Department

of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

4Department

of Neurology, New York University School of Medicine, New York, NY, USA

5Department

of Neurology and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Abstract

Author Manuscript Author Manuscript

Our aim is to characterize the nature and extent of pathological changes in the normal-appearing white matter (NAWM) of patients with multiple sclerosis (MS) using novel diffusion kurtosis imaging-derived white matter tract integrity (WMTI) metrics, and to investigate the association between these WMTI metrics and clinical parameters. 32 patients with relapsing-remitting MS and 19 age- and gender-matched healthy controls underwent MRI and neurological examination. Maps of mean diffusivity, fractional anisotropy and WMTI metrics (intra-axonal diffusivity, axonal water fraction, tortuosity and axial and radial extra-axonal diffusivity) were created. Tract-based spatial statistics analysis was performed to assess for differences in the NAWM between patients and controls. A region of interest analysis of the corpus callosum was also performed to assess for group differences and to evaluate correlations between WMTI metrics and measures of disease severity. Mean diffusivity and radial extra-axonal diffusivity were significantly increased while fractional anisotropy, axonal water fraction, intra-axonal diffusivity and tortuosity were decreased in MS patients compared with controls (p values ranging from

Quantification of normal-appearing white matter tract integrity in multiple sclerosis: a diffusion kurtosis imaging study.

Our aim was to characterize the nature and extent of pathological changes in the normal-appearing white matter (NAWM) of patients with multiple sclero...
672KB Sizes 0 Downloads 23 Views