hlrd

of chromatogrcrpky, 170

(1979) 473-m

Scienti!& Publishing Company, Amsterdti - printed in The N&e&u&

a wsevier

CHROM. 11,456 .’

_..

Note

:

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%

.. .

.>L ._

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.

“_‘.;[ :_ ::-

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. . _.y:_.-

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Quantitative gas-liquid chromatagraphic methyi-nnilproxen SUK HAN WAN

and their

and SHAKEI

conjugates~in

analFir_

of

wine

~~aprcm&

;b_des_ .

I

,-

B. MATIN

; _ ; .: -_: i_ -.

llie School of Pkamracy, Universityof So&rem .Califomia:Los Angeles, Wifonka and tixe.Depw&ent ‘.,z:,; of De Me&o&m, Sytttex Research, Pdo. Alto, Calif. ( ff_S& .

(Receii

August gth,

1978)

“.:.

Naproxen [(+)-6-methoxy-a-methyl-2-naphthaleneacetic ,acidl _.& a-ne& ‘&n-~ steroidal, anti-inflammatory agent &at also has antipyretic and analgesic &.$&. Xi is well-absorbed orally and has an elimination haif-lifeofabout 14 h. IIXma_n;5%@0~~ of an orally administered dose of naproxen can be recovered in tine in-;&e form of naproxen, QO-desmethyi-naproxen and their giucuronide conjugate+3. A g&-Ii&&i chromatographic (GLC) technique has been reported for the analysis of naproxen in plasma in which methylation of the carboxylic a,cid group wit@ &,azo&&an~~ is achieved prior to chromatogr&phy 2*4_This method & not appti@&z. to .&&en ,.i analysis in urine bec+se of presence of m-&G +etabolites. _. Severai reports have described the successful application dfGJ.$ in&t; a&&& of barbituric acids, diphenylhydantoin, purines, p$imidi&s and u&ii ‘IBY