JFDA92_proof ■ 1 February 2014 ■ 1/20 j o u r n a l o f f o o d a n d d r u g a n a l y s i s x x x ( 2 0 1 4 ) 1 e2 0
Available online at www.sciencedirect.com 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64
ScienceDirect journal homepage: www.jfda-online.com
Review Article
Raman spectroscopy in the analysis of food and pharmaceutical nanomaterials Q44
Ying-Sing Li a,*, Jeffrey S. Church b a b
Department of Chemistry, University of Memphis, Memphis, TN 38152, USA CSIRO Materials Science and Engineering, PO Box 21, Belmont, VIC 3216, Australia
article info
abstract
Article history:
Raman scattering is an inelastic phenomenon. Although its cross section is very small,
Received 30 September 2013
recent advances in electronics, lasers, optics, and nanotechnology have made Raman
Accepted 21 November 2013
spectroscopy suitable in many areas of application. The present article reviews the ap-
Available online xxx
plications of Raman spectroscopy in food and drug analysis and inspection, including those associated with nanomaterials. Brief overviews of the basic Raman scattering theory,
Keywords:
instrumentation, and statistical data analysis are also given. With the advent of Raman
Food
enhancement mechanisms and the progress being made in metal nanomaterials and
Nanomaterials
nanoscale metal surfaces fabrications, surface enhanced Raman scattering spectroscopy
Pharmaceuticals
has become an extra sensitive method, which is applicable not only for analysis of foods
Raman cell imaging
and drugs, but also for intracellular and intercellular imaging. A Raman spectrometer
Raman spectroscopy
coupled with a fiber optics probe has great potential in applications such as monitoring and quality control in industrial food processing, food safety in agricultural plant production, and convenient inspection of pharmaceutical products, even through different types of packing. A challenge for the routine application of surface enhanced Raman scattering for quantitative analysis is reproducibility. Success in this area can be approached with each or a combination of the following methods: (1) fabrication of nanostructurally regular and uniform substrates; (2) application of statistic data analysis; and (3) isotopic dilution. Copyright ª 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.
Q2
1.
Introduction
Nanomaterials are engineered particles with the shortest dimension