Clinical Science (1991) 80,505-508
505
Ranitidine suppresses aluminium absorption in man R. S. C. RODGER*, G. S. MURAUKRISHNA*, D. J. HALLSt, J. B. HENDERSON* J. A. H. FORREST:j:, A. 1. MACDOUGALL* AND G. s. FELLt ' *Renal Unit and tGastroenterology Unit, Stobhill General Hospital, Glasgow, and tTrace Element Unit, Institute of Biochemistry, Royal Infirmary, Glasgow, U.K.
(Received 14 Septemberj22 November 1990; accepted 31 December 1990) SUMMARY 1. Intragastric pH monitoring was performed before and after the single-blind administration of ranitidine or placebo (saline) in eight healthy subjects and four patients with end-stage renal disease who were on regular haemodialysis. 2. The subjects were studied on two occasions and were given aluminium hydroxide (1185 mg) orally 90 min after the administration of ranitidine or saline. 3. Plasma aluminium concentrations and, in normal men, urinary excretion of aluminium were monitored before and after the oral aluminium load. 4. Intragastric pH increased significantly with ranitidine but not with placebo (P< 0.001). Urinary aluminium excretion increased significantly after the administration of aluminium hydroxide during the placebo phase (P
505
Ranitidine suppresses aluminium absorption in man R. S. C. RODGER*, G. S. MURAUKRISHNA*, D. J. HALLSt, J. B. HENDERSON* J. A. H. FORREST:j:, A. 1. MACDOUGALL* AND G. s. FELLt ' *Renal Unit and tGastroenterology Unit, Stobhill General Hospital, Glasgow, and tTrace Element Unit, Institute of Biochemistry, Royal Infirmary, Glasgow, U.K.
(Received 14 Septemberj22 November 1990; accepted 31 December 1990) SUMMARY 1. Intragastric pH monitoring was performed before and after the single-blind administration of ranitidine or placebo (saline) in eight healthy subjects and four patients with end-stage renal disease who were on regular haemodialysis. 2. The subjects were studied on two occasions and were given aluminium hydroxide (1185 mg) orally 90 min after the administration of ranitidine or saline. 3. Plasma aluminium concentrations and, in normal men, urinary excretion of aluminium were monitored before and after the oral aluminium load. 4. Intragastric pH increased significantly with ranitidine but not with placebo (P< 0.001). Urinary aluminium excretion increased significantly after the administration of aluminium hydroxide during the placebo phase (P
