UROLITHIASIS/ENDOUROLOGY
2
calcium excretion was similar in the stone formers and the control cohort. The reasons for this finding are unclear. Dean G. Assimos, MD
Suggested Reading Nishijima S, Sugaya K, Naito A et al: Association of vitamin D receptor gene polymorphism with urolithiasis. J Urol 2002; 167: 2188. Dinour D, Beckerman P, Ganon L et al: Loss-of-function mutations of CYP24A1, the vitamin D 24-hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis. J Urol 2013; 190: 552.
Re: Alkali Replacement Raises Urinary Citrate Excretion in Patients with Topiramate-Induced Hypocitraturia R. A. Jhagroo, M. L. Wertheim and K. L. Penniston Departments of Medicine and Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Br J Clin Pharmacol 2015; Epub ahead of print. doi: 10.1111/bcp.12751
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/26297809 Editorial Comment: Topiramate is used to treat patients with migraine headaches as well as seizures. It is a carbonic anhydrase inhibitor that promotes a response similar to renal tubular acidosis, low citrate and increased urine pH. This milieu favors the formation of calcium phosphate stones. These investigators demonstrated that supplemental potassium citrate improved citrate excretion. However, urinary pH remained on the high side, a risk factor for calcium phosphate stone formation. Dean G. Assimos, MD
Suggested Reading Astroza GM, Neisius A, Tsivian M et al: Treatment response in stone patients with low urinary pH and hypocitraturia stratified by body mass index. J Urol 2015; Epub ahead of print. Barcelo P, Wuhl O, Servitge E et al: Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol 1993; 150: 1761.
Re: EAU Guidelines on Interventional Treatment for Urolithiasis € rk, A. Petrı´k, K. Sarica, C. Seitz, A. Skolarikos, M. Straub and T. Knoll C. Tu jovice, Czech Republic, ´ Bude Departments of Urology, Rudolfstiftung Hospital and Medical University Vienna, Vienna, Austria, Region Hospital, Ceske Dr. Lutfi Kirdar Kartal Research and Training Hospital, Istanbul, Turkey, and Technical University Munich, Munich and Sindelfingen-Bo¨blingen Medical Centre, University of Tu¨bingen, Sindelfingen, Germany, and Second Department of Urology, Sismanoglio Hospital, Athens Medical School, Athens, Greece Eur Urol 2015; Epub ahead of print. doi: 10.1016/j.eururo.2015.07.041
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/26344917 Editorial Comment: This European Association of Urology document provides evidence-based guidelines for treating patients with ureteral and renal stones. Unique features include recommendations for patient selection based on imaging criteria as well as technical aspects of stone removal. It is anticipated that American Urological Association (AUA) guidelines for surgical management of stones will be released just before the 2016 AUA meeting. Dean G. Assimos, MD
Suggested Reading Preminger GM, Assimos DG, Lingeman JE et al: AUA Nephrolithiasis Guideline Panel: Chapter 1: AUA guideline on management of staghorn calculi: diagnosis and treatment recommendations. J Urol 2005; 173: 1991. Preminger GM, Tiselius HG, Assimos DG et al: EAU/AUA Nephrolithiasis Guideline Panel: 2007 Guideline for the management of ureteral calculi. J Urol 2007; 178: 2418.
2
calcium excretion was similar in the stone formers and the control cohort. The reasons for this finding are unclear. Dean G. Assimos, MD
Suggested Reading Nishijima S, Sugaya K, Naito A et al: Association of vitamin D receptor gene polymorphism with urolithiasis. J Urol 2002; 167: 2188. Dinour D, Beckerman P, Ganon L et al: Loss-of-function mutations of CYP24A1, the vitamin D 24-hydroxylase gene, cause long-standing hypercalciuric nephrolithiasis and nephrocalcinosis. J Urol 2013; 190: 552.
Re: Alkali Replacement Raises Urinary Citrate Excretion in Patients with Topiramate-Induced Hypocitraturia R. A. Jhagroo, M. L. Wertheim and K. L. Penniston Departments of Medicine and Urology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin Br J Clin Pharmacol 2015; Epub ahead of print. doi: 10.1111/bcp.12751
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/26297809 Editorial Comment: Topiramate is used to treat patients with migraine headaches as well as seizures. It is a carbonic anhydrase inhibitor that promotes a response similar to renal tubular acidosis, low citrate and increased urine pH. This milieu favors the formation of calcium phosphate stones. These investigators demonstrated that supplemental potassium citrate improved citrate excretion. However, urinary pH remained on the high side, a risk factor for calcium phosphate stone formation. Dean G. Assimos, MD
Suggested Reading Astroza GM, Neisius A, Tsivian M et al: Treatment response in stone patients with low urinary pH and hypocitraturia stratified by body mass index. J Urol 2015; Epub ahead of print. Barcelo P, Wuhl O, Servitge E et al: Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. J Urol 1993; 150: 1761.
Re: EAU Guidelines on Interventional Treatment for Urolithiasis € rk, A. Petrı´k, K. Sarica, C. Seitz, A. Skolarikos, M. Straub and T. Knoll C. Tu jovice, Czech Republic, ´ Bude Departments of Urology, Rudolfstiftung Hospital and Medical University Vienna, Vienna, Austria, Region Hospital, Ceske Dr. Lutfi Kirdar Kartal Research and Training Hospital, Istanbul, Turkey, and Technical University Munich, Munich and Sindelfingen-Bo¨blingen Medical Centre, University of Tu¨bingen, Sindelfingen, Germany, and Second Department of Urology, Sismanoglio Hospital, Athens Medical School, Athens, Greece Eur Urol 2015; Epub ahead of print. doi: 10.1016/j.eururo.2015.07.041
Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/26344917 Editorial Comment: This European Association of Urology document provides evidence-based guidelines for treating patients with ureteral and renal stones. Unique features include recommendations for patient selection based on imaging criteria as well as technical aspects of stone removal. It is anticipated that American Urological Association (AUA) guidelines for surgical management of stones will be released just before the 2016 AUA meeting. Dean G. Assimos, MD
Suggested Reading Preminger GM, Assimos DG, Lingeman JE et al: AUA Nephrolithiasis Guideline Panel: Chapter 1: AUA guideline on management of staghorn calculi: diagnosis and treatment recommendations. J Urol 2005; 173: 1991. Preminger GM, Tiselius HG, Assimos DG et al: EAU/AUA Nephrolithiasis Guideline Panel: 2007 Guideline for the management of ureteral calculi. J Urol 2007; 178: 2418.
