Clin Physiol Funct Imaging (2015)
doi: 10.1111/cpf.12238
Red blood cell sodium transport in patients with cirrhosis €tken Henriksen1, Marianne Kiszka-Kanowitz2, Flemming Bendtsen2 and Jens H. Henriksen1 Ulrik Lu 1
Department of Clinical Physiology 239, Center for Functional and Diagnostic Imaging and Research, and 2Gastrounit Medical Division, Hvidovre Hospital, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark
Summary Correspondence Professor Jens H. Henriksen, MD, Department of Clinical Physiology, 239, Center for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, University of Copenhagen, DK-2650 Hvidovre, Denmark E-mail: [email protected]
Accepted for publication Received 3 October 2014; accepted 27 January 2015
Key words homoeostatic sodium dysregulation; hyponatremia; sodium retention; sodium–potassium ATPase; tracer kinetics
Patients with advanced cirrhosis have abnormal sodium homoeostasis. The study was undertaken to quantify the sodium transport across the plasma membrane of red blood cells (RBC) in patients with cirrhosis. RBC efflux and influx of sodium were studied in vitro with tracer 22Na+ according to linear kinetics in 24 patients with cirrhosis and 14 healthy controls. The sodium efflux was modified by ouabain (O), furosemide (F) and a combination of O and F (O + F). RBC sodium was significantly decreased (46 versus control 63 mmol l 1, P
doi: 10.1111/cpf.12238
Red blood cell sodium transport in patients with cirrhosis €tken Henriksen1, Marianne Kiszka-Kanowitz2, Flemming Bendtsen2 and Jens H. Henriksen1 Ulrik Lu 1
Department of Clinical Physiology 239, Center for Functional and Diagnostic Imaging and Research, and 2Gastrounit Medical Division, Hvidovre Hospital, Faculty of Medicine and Health Sciences, University of Copenhagen, Copenhagen, Denmark
Summary Correspondence Professor Jens H. Henriksen, MD, Department of Clinical Physiology, 239, Center for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, University of Copenhagen, DK-2650 Hvidovre, Denmark E-mail: [email protected]
Accepted for publication Received 3 October 2014; accepted 27 January 2015
Key words homoeostatic sodium dysregulation; hyponatremia; sodium retention; sodium–potassium ATPase; tracer kinetics
Patients with advanced cirrhosis have abnormal sodium homoeostasis. The study was undertaken to quantify the sodium transport across the plasma membrane of red blood cells (RBC) in patients with cirrhosis. RBC efflux and influx of sodium were studied in vitro with tracer 22Na+ according to linear kinetics in 24 patients with cirrhosis and 14 healthy controls. The sodium efflux was modified by ouabain (O), furosemide (F) and a combination of O and F (O + F). RBC sodium was significantly decreased (46 versus control 63 mmol l 1, P
