Clinical Science (1992) 83, 695-7M (Printed in Great Britain)
695
Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloridetreated rats effect of zinc administration Jordi CAMPS*, Teresa BARGALLO?, America GIMENEZS, Silvia ALIES, Joan CABALLERIAS, Albert PARES$, Jorge JOVEN*, Lluis MASANAt and Joan RODESS *Centre de Recerca BiomMica, Hospital de Sant Joan de Reus, Reus, Spain, tunitat de Recerca de lipids, Facultat de Medicina de Reus, Reus, Spain, and Sliver Unit, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain (Received 24 April/) August 1992; accepted 6 August 1992)
1. Lipid peroxidation and hepatic fibrogenesis were investigated in 25 carbon tetrachloride-treated rats and in 25 control animals. Rats were further divided into two groups to receive either a standard diet or one supplemented with zinc. From each group, animals were killed at weeks 3 and 18 of the experiment for histological and biochemical assessments which included hepatic lipid peroxide and collagen concentrations and plasma zinc concentration as well as the hepatic activities of proline hydroxylase and collagenase. 2. Results indicated that oral zinc supplementation was associated with a decrease in lipid peroxidation (mean 51%; P
695
Relationship between hepatic lipid peroxidation and fibrogenesis in carbon tetrachloridetreated rats effect of zinc administration Jordi CAMPS*, Teresa BARGALLO?, America GIMENEZS, Silvia ALIES, Joan CABALLERIAS, Albert PARES$, Jorge JOVEN*, Lluis MASANAt and Joan RODESS *Centre de Recerca BiomMica, Hospital de Sant Joan de Reus, Reus, Spain, tunitat de Recerca de lipids, Facultat de Medicina de Reus, Reus, Spain, and Sliver Unit, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain (Received 24 April/) August 1992; accepted 6 August 1992)
1. Lipid peroxidation and hepatic fibrogenesis were investigated in 25 carbon tetrachloride-treated rats and in 25 control animals. Rats were further divided into two groups to receive either a standard diet or one supplemented with zinc. From each group, animals were killed at weeks 3 and 18 of the experiment for histological and biochemical assessments which included hepatic lipid peroxide and collagen concentrations and plasma zinc concentration as well as the hepatic activities of proline hydroxylase and collagenase. 2. Results indicated that oral zinc supplementation was associated with a decrease in lipid peroxidation (mean 51%; P
