AMER IC AN JOURNAL OF OT OLA RYNGOLOGY– H E A D A N D NE CK M E D ICI N E AN D S U RGE RY X X (2 0 1 5) XXX – XXX
Available online at www.sciencedirect.com
ScienceDirect www.elsevier.com/locate/amjoto
Original contribution
Relationship between obesity, diabetes and the risk of thyroid cancer☆,☆☆,★ Benjamin Oberman, MD a , Aliasgher Khaku, BS a , Fabian Camacho, MS, MA b , David Goldenberg, MD a,⁎ a
Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA Department of Public Health Sciences, Division of Health Services and Behavioral Research, The Pennsylvania State University, College of Medicine, Hershey, PA, USA b
ARTI CLE I NFO
A BS TRACT
Article history:
Purpose: Analyze the relationship between obesity and type-2 diabetes mellitus (DM) and
Received 5 January 2015
the development of differentiated thyroid cancer (DTC). Materials and methods: A randomized case-controlled retrospective chart review of outpatient clinic patients at an academic medical center between January 2005 and December 2012. DTC patients were compared to two control groups: primary hyperparathyroidism (PHPTH) patients with euthyroid state and Internal Medicine (IM) patients. Exposure variables included historical body-mass-index (BMI), most recent BMI within 6 months and DM. Multivariate logistic regressions adjusting for gender, age, and year of BMI assessed the adjusted Odds Ratio (OR) of DTC with both BMI and DM. Results: Comparison of means showed a statistically significant higher BMI in DTC (BMI = 37.83) than PHPTH, IM, and pooled controls, BMI = 30.36 p = 30.0 Historical BMI (kg/m2) > 30.0 Type-II diabetes
DTC compared to control group 1 (PHPTH)
DTC compared to control group 2 (IM)
OR (95% CI)
p value
OR (95% CI)
p value
OR (95% CI)
p value
2.299 1.103 1.125 1.112 3.178
0.0011 0.0001 0.0001 0.0021 0.0198
3.363 1.127 1.154 1.122 1.860
Available online at www.sciencedirect.com
ScienceDirect www.elsevier.com/locate/amjoto
Original contribution
Relationship between obesity, diabetes and the risk of thyroid cancer☆,☆☆,★ Benjamin Oberman, MD a , Aliasgher Khaku, BS a , Fabian Camacho, MS, MA b , David Goldenberg, MD a,⁎ a
Department of Surgery, Division of Otolaryngology–Head and Neck Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA, USA Department of Public Health Sciences, Division of Health Services and Behavioral Research, The Pennsylvania State University, College of Medicine, Hershey, PA, USA b
ARTI CLE I NFO
A BS TRACT
Article history:
Purpose: Analyze the relationship between obesity and type-2 diabetes mellitus (DM) and
Received 5 January 2015
the development of differentiated thyroid cancer (DTC). Materials and methods: A randomized case-controlled retrospective chart review of outpatient clinic patients at an academic medical center between January 2005 and December 2012. DTC patients were compared to two control groups: primary hyperparathyroidism (PHPTH) patients with euthyroid state and Internal Medicine (IM) patients. Exposure variables included historical body-mass-index (BMI), most recent BMI within 6 months and DM. Multivariate logistic regressions adjusting for gender, age, and year of BMI assessed the adjusted Odds Ratio (OR) of DTC with both BMI and DM. Results: Comparison of means showed a statistically significant higher BMI in DTC (BMI = 37.83) than PHPTH, IM, and pooled controls, BMI = 30.36 p = 30.0 Historical BMI (kg/m2) > 30.0 Type-II diabetes
DTC compared to control group 1 (PHPTH)
DTC compared to control group 2 (IM)
OR (95% CI)
p value
OR (95% CI)
p value
OR (95% CI)
p value
2.299 1.103 1.125 1.112 3.178
0.0011 0.0001 0.0001 0.0021 0.0198
3.363 1.127 1.154 1.122 1.860
