Alimentary Pharmacology and Therapeutics
Relative adrenal insufficiency in chronic liver disease: its prevalence and effects on long-term mortality J. Y. Jang*,1, T. Y. Kim†,1, J. H. Sohn†, T. H. Lee*, S. W. Jeong*, E. J. Park*, S. H. Lee*, S. G. Kim*, Y. S. Kim*, H. S. Kim* & B. S. Kim*
*Division of Gastroenterology, Department of Internal Medicine, Digestive Disease Center, Institute for Digestive Research, College of Medicine, Soonchunhyang University, Seoul, South Korea. † Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea.
Correspondence to: Dr J. H. Sohn, Department of Internal Medicine, Hanyang University Guri Hospital, 153 Gyeongchun-ro, Guri 471-701, Korea. E-mail: [email protected] The first two authors (Jae Young Jang and Tae Yeob Kim) contributed equally to this work. 1
Publication data Submitted 7 April 2014 First decision 29 April 2014 Resubmitted 4 June 2014 Resubmitted 6 July 2014 Accepted 7 July 2014 EV Pub Online 30 July 2014 This article was accepted for publication after full peer-review.
SUMMARY Background The relationship between relative adrenal insufficiency (RAI) and chronic liver disease is unclear. Aim To determine the frequency with which RAI is observed in noncritically ill patients at various stages of chronic liver disease, and the correlation between RAI and disease severity and long-term mortality. Methods In total, 71 non-critically ill patients with liver cirrhosis (n = 54) and chronic hepatitis (n = 17) were evaluated prospectively. A short stimulation test (SST) with 250 lg of corticotrophin was performed to detect RAI. RAI was defined as an increase in serum cortisol of
Relative adrenal insufficiency in chronic liver disease: its prevalence and effects on long-term mortality J. Y. Jang*,1, T. Y. Kim†,1, J. H. Sohn†, T. H. Lee*, S. W. Jeong*, E. J. Park*, S. H. Lee*, S. G. Kim*, Y. S. Kim*, H. S. Kim* & B. S. Kim*
*Division of Gastroenterology, Department of Internal Medicine, Digestive Disease Center, Institute for Digestive Research, College of Medicine, Soonchunhyang University, Seoul, South Korea. † Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea.
Correspondence to: Dr J. H. Sohn, Department of Internal Medicine, Hanyang University Guri Hospital, 153 Gyeongchun-ro, Guri 471-701, Korea. E-mail: [email protected] The first two authors (Jae Young Jang and Tae Yeob Kim) contributed equally to this work. 1
Publication data Submitted 7 April 2014 First decision 29 April 2014 Resubmitted 4 June 2014 Resubmitted 6 July 2014 Accepted 7 July 2014 EV Pub Online 30 July 2014 This article was accepted for publication after full peer-review.
SUMMARY Background The relationship between relative adrenal insufficiency (RAI) and chronic liver disease is unclear. Aim To determine the frequency with which RAI is observed in noncritically ill patients at various stages of chronic liver disease, and the correlation between RAI and disease severity and long-term mortality. Methods In total, 71 non-critically ill patients with liver cirrhosis (n = 54) and chronic hepatitis (n = 17) were evaluated prospectively. A short stimulation test (SST) with 250 lg of corticotrophin was performed to detect RAI. RAI was defined as an increase in serum cortisol of
