Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp
ORIGINAL ARTICLE Heart Failure
Renal Function and Peak Exercise Oxygen Consumption in Chronic Heart Failure With Reduced Left Ventricular Ejection Fraction Domenico Scrutinio, MD; Piergiuseppe Agostoni, MD, PhD; Loreto Gesualdo, MD; Ugo Corrà, MD; Alessandro Mezzani, MD; Massimo Piepoli, MD; Andrea Di Lenarda, MD; Annamaria Iorio, MD; Claudio Passino, MD; Damiano Magrì, MD, PhD; Daniele Masarone, MD; Elisa Battaia, MD; Davide Girola, MD; Federica Re, MD; Gaia Cattadori, MD; Gianfranco Parati, MD; Gianfranco Sinagra, MD; Giovanni Quinto Villani, MD; Giuseppe Limongelli, MD; Giuseppe Pacileo, MD; Marco Guazzi, MD; Marco Metra, MD; Maria Frigerio, MD; Mariantonietta Cicoira, MD; Chiara Minà, MD; Gabriella Malfatto, MD, PhD; Sergio Caravita, MD; Maurizio Bussotti, MD; Elisabetta Salvioni, PhD; Fabrizio Veglia, PhD; Michele Correale, MD; Angela B. Scardovi, MD; Michele Emdin, MD; Pantaleo Giannuzzi, MD; Paola Gargiulo, MD; Marta Giovannardi, BSc; Pasquale Perrone-Filardi, MD; Rosa Raimondo, MD; Roberto Ricci, MD; Stefania Paolillo, MD; Stefania Farina, MD; Romualdo Belardinelli, MD; Andrea Passantino, MD; Rocco La Gioia, MD on behalf of the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) Score Research Group
Background: Chronic kidney disease is associated with sympathetic activation and muscle abnormalities, which may contribute to decreased exercise capacity. We investigated the correlation of renal function with peak exercise oxygen consumption (V˙ O2) in heart failure (HF) patients. Methods and Results: We recruited 2,938 systolic HF patients who underwent clinical, laboratory, echocardiographic and cardiopulmonary exercise testing. The patients were stratified according to estimated glomerular filtration rate (eGFR). Mean follow-up was 3.7 years. The primary outcome was a composite of cardiovascular death and urgent heart transplantation at 3 years. On multivariable regression, eGFR was predictor of peakV˙ O2 (P
ORIGINAL ARTICLE Heart Failure
Renal Function and Peak Exercise Oxygen Consumption in Chronic Heart Failure With Reduced Left Ventricular Ejection Fraction Domenico Scrutinio, MD; Piergiuseppe Agostoni, MD, PhD; Loreto Gesualdo, MD; Ugo Corrà, MD; Alessandro Mezzani, MD; Massimo Piepoli, MD; Andrea Di Lenarda, MD; Annamaria Iorio, MD; Claudio Passino, MD; Damiano Magrì, MD, PhD; Daniele Masarone, MD; Elisa Battaia, MD; Davide Girola, MD; Federica Re, MD; Gaia Cattadori, MD; Gianfranco Parati, MD; Gianfranco Sinagra, MD; Giovanni Quinto Villani, MD; Giuseppe Limongelli, MD; Giuseppe Pacileo, MD; Marco Guazzi, MD; Marco Metra, MD; Maria Frigerio, MD; Mariantonietta Cicoira, MD; Chiara Minà, MD; Gabriella Malfatto, MD, PhD; Sergio Caravita, MD; Maurizio Bussotti, MD; Elisabetta Salvioni, PhD; Fabrizio Veglia, PhD; Michele Correale, MD; Angela B. Scardovi, MD; Michele Emdin, MD; Pantaleo Giannuzzi, MD; Paola Gargiulo, MD; Marta Giovannardi, BSc; Pasquale Perrone-Filardi, MD; Rosa Raimondo, MD; Roberto Ricci, MD; Stefania Paolillo, MD; Stefania Farina, MD; Romualdo Belardinelli, MD; Andrea Passantino, MD; Rocco La Gioia, MD on behalf of the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) Score Research Group
Background: Chronic kidney disease is associated with sympathetic activation and muscle abnormalities, which may contribute to decreased exercise capacity. We investigated the correlation of renal function with peak exercise oxygen consumption (V˙ O2) in heart failure (HF) patients. Methods and Results: We recruited 2,938 systolic HF patients who underwent clinical, laboratory, echocardiographic and cardiopulmonary exercise testing. The patients were stratified according to estimated glomerular filtration rate (eGFR). Mean follow-up was 3.7 years. The primary outcome was a composite of cardiovascular death and urgent heart transplantation at 3 years. On multivariable regression, eGFR was predictor of peakV˙ O2 (P
