Tropical Medicine and International Health
doi:10.1111/tmi.12446
volume 00 no 00
Renal impairment in HIV-infected patients initiating tenofovircontaining antiretroviral therapy regimens in a Primary Healthcare Setting in South Africa Monika Kamkuemah1, Richard Kaplan2, Linda-Gail Bekker2, Francesca Little3 and Landon Myer1,2 1 Division of Epidemiology & Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa 2 Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa 3 Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa
Abstract
objective Long-term use of tenofovir disoproxil fumarate is associated with declines in glomerular function and chronic kidney disease in HIV-infected patients. We aimed to assess the prevalence and incidence of renal impairment in a primary care setting in sub-Saharan Africa. methods We analysed data from 1092 HIV-infected patients initiating tenofovir at a primary care clinic in Cape Town, South Africa. Renal function was assessed for the first 12 months on ART by estimating glomerular filtration rate (eGFR) calculated using the Cockroft–Gault equation categorised into normal, mild, moderate and severe reduction in renal function based on values >90, 60–89, 30– 59 and 60 ml/min/1.73 m2. ‡Patients with no severe or moderate renal function impairment at baseline (eGFR >60 ml/min/1.73 m2). §95% confidence interval derived from the Poisson distribution. Table 4 Linear models for continuous change in eGFR at month 12
Variable SCr Month 1¶ SCr Month 2¶ SCr Month 4¶
Univariate* estimate 0.023 0.149 0.220
95% CI† ( 0.039; ( 0.203; ( 0.310;
R-squared 0.007) 0.095) 0.130)
0.002 0.018 0.020
Multivariate‡ estimate 0.054 0.222 0.362
95% CI ( 0.077; ( 0.283; ( 0.460;
R-squared 0.030) 0.161) 0.263)
0.126 0.147 0.157
Chi-squared P-value§
doi:10.1111/tmi.12446
volume 00 no 00
Renal impairment in HIV-infected patients initiating tenofovircontaining antiretroviral therapy regimens in a Primary Healthcare Setting in South Africa Monika Kamkuemah1, Richard Kaplan2, Linda-Gail Bekker2, Francesca Little3 and Landon Myer1,2 1 Division of Epidemiology & Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa 2 Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa 3 Department of Statistical Sciences, University of Cape Town, Cape Town, South Africa
Abstract
objective Long-term use of tenofovir disoproxil fumarate is associated with declines in glomerular function and chronic kidney disease in HIV-infected patients. We aimed to assess the prevalence and incidence of renal impairment in a primary care setting in sub-Saharan Africa. methods We analysed data from 1092 HIV-infected patients initiating tenofovir at a primary care clinic in Cape Town, South Africa. Renal function was assessed for the first 12 months on ART by estimating glomerular filtration rate (eGFR) calculated using the Cockroft–Gault equation categorised into normal, mild, moderate and severe reduction in renal function based on values >90, 60–89, 30– 59 and 60 ml/min/1.73 m2. ‡Patients with no severe or moderate renal function impairment at baseline (eGFR >60 ml/min/1.73 m2). §95% confidence interval derived from the Poisson distribution. Table 4 Linear models for continuous change in eGFR at month 12
Variable SCr Month 1¶ SCr Month 2¶ SCr Month 4¶
Univariate* estimate 0.023 0.149 0.220
95% CI† ( 0.039; ( 0.203; ( 0.310;
R-squared 0.007) 0.095) 0.130)
0.002 0.018 0.020
Multivariate‡ estimate 0.054 0.222 0.362
95% CI ( 0.077; ( 0.283; ( 0.460;
R-squared 0.030) 0.161) 0.263)
0.126 0.147 0.157
Chi-squared P-value§
