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Illuminations September-October 2017 • Volume 37 • Number 5
Renal Medullary Carcinoma Associated with Sickle Cell Trait
Medullary carcinoma affects adolescents and young adults with sickle cell trait or heterozygous sickle cell disease (middle illustration). On US (top left) and CT (bottom left) images, the tumor demonstrates an infiltrative pattern, which expands but preserves the reniform shape. At histologic examination (top right), the tumor is marginated with inflammatory cells. Medullary carcinoma forms a large mass centered in the renal medulla, with satellite nodules in the adjacent renal cortex (bottom right). Extensive metastatic disease to the nodes, bone, and lung is typical, and the prognosis is poor. Medical Illustration © Aletta Ann Frazier, MD, American Institute for Radiologic Pathology, Silver Spring, Maryland, and University of Maryland School of Medicine, Baltimore, Maryland ([email protected]).
ILLUMINATIONS
1537
Illuminations September-October 2017 • Volume 37 • Number 5
Renal Medullary Carcinoma Associated with Sickle Cell Trait
Medullary carcinoma affects adolescents and young adults with sickle cell trait or heterozygous sickle cell disease (middle illustration). On US (top left) and CT (bottom left) images, the tumor demonstrates an infiltrative pattern, which expands but preserves the reniform shape. At histologic examination (top right), the tumor is marginated with inflammatory cells. Medullary carcinoma forms a large mass centered in the renal medulla, with satellite nodules in the adjacent renal cortex (bottom right). Extensive metastatic disease to the nodes, bone, and lung is typical, and the prognosis is poor. Medical Illustration © Aletta Ann Frazier, MD, American Institute for Radiologic Pathology, Silver Spring, Maryland, and University of Maryland School of Medicine, Baltimore, Maryland ([email protected]).
ILLUMINATIONS
1537
