ANIMAL STUDY e-ISSN 1643-3750 © Med Sci Monit, 2015; 21: 2886-2892 DOI: 10.12659/MSM.895543
Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying Mechanism
Received: 2015.08.03 Accepted: 2015.09.08 Published: 2015.09.26
Authors’ ABCDEF Contribution: Na Wang Study Design A AEG Ri-bao Wei Data Collection B B Qing-ping Li Statistical Analysis C Data Interpretation B D Xi Yang Manuscript Preparation E C Ping Li Literature Search F D Meng-jie Huang Funds Collection G
Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, P.R. China
D Rui Wang
A Guang-yan Cai E Xiang-mei Chen
Corresponding Author: Source of support:
Ri-bao Wei, e-mail: [email protected] This work was supported by grants from the National Sciences Foundation of China (81273968 and 81471027), Ministerial projects of the National Working Commission on Aging (QLB2014W002),and The Four hundred project of 301 (YS201408)
Background:
Material/Methods:
Results:
Conclusions:
Contrast-induced nephropathy (CIN) refers to acute renal damage that occurs after the use of contrast agents. This study investigated the renal protective effect of probucol in a rat model of contrast-induced nephropathy and the mechanism of its effect. Twenty-eight Wistar rats were randomly divided into the control group, model group, N-acetylcysteine(NAC) group, and probucol group. We used a rat model of iopromide-induced CIN. One day prior to modeling, the rats received gavage. At 24 h after the modeling, blood biochemistry and urine protein were assessed. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in renal tissue. Kidney sections were created for histopathological examination. The model group of rats showed significantly elevated levels of blood creatinine, urea nitrogen, 24-h urine protein, histopathological scores, and parameters of oxidative stress (P
Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying Mechanism
Received: 2015.08.03 Accepted: 2015.09.08 Published: 2015.09.26
Authors’ ABCDEF Contribution: Na Wang Study Design A AEG Ri-bao Wei Data Collection B B Qing-ping Li Statistical Analysis C Data Interpretation B D Xi Yang Manuscript Preparation E C Ping Li Literature Search F D Meng-jie Huang Funds Collection G
Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, P.R. China
D Rui Wang
A Guang-yan Cai E Xiang-mei Chen
Corresponding Author: Source of support:
Ri-bao Wei, e-mail: [email protected] This work was supported by grants from the National Sciences Foundation of China (81273968 and 81471027), Ministerial projects of the National Working Commission on Aging (QLB2014W002),and The Four hundred project of 301 (YS201408)
Background:
Material/Methods:
Results:
Conclusions:
Contrast-induced nephropathy (CIN) refers to acute renal damage that occurs after the use of contrast agents. This study investigated the renal protective effect of probucol in a rat model of contrast-induced nephropathy and the mechanism of its effect. Twenty-eight Wistar rats were randomly divided into the control group, model group, N-acetylcysteine(NAC) group, and probucol group. We used a rat model of iopromide-induced CIN. One day prior to modeling, the rats received gavage. At 24 h after the modeling, blood biochemistry and urine protein were assessed. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in renal tissue. Kidney sections were created for histopathological examination. The model group of rats showed significantly elevated levels of blood creatinine, urea nitrogen, 24-h urine protein, histopathological scores, and parameters of oxidative stress (P
