Cellular Physiology and Biochemistry
Cell Physiol Biochem 2014;33:1663-1680 DOI: 10.1159/000362950 Published online: May 16, 2014
© 2014 S. Karger AG, Basel www.karger.com/cpb
Chen et al.:April EETs07, and2014 Lung Ischemia/Reperfusion Injury Accepted: 1421-9778/14/0336-1663$39.50/0 This is an Open Access article licensed under the terms of the Creative Commons AttributionNonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Original Paper
CYP2J2 and EETs Protect against Oxidative Stress and Apoptosis in Vivo and in Vitro Following Lung Ischemia/Reperfusion Wenshu Chena,b,f Guanying Zhengc,f Shijiang Yangd Wei Pinga Xiangning Fua Ni Zhanga Dao Wen Wange Jianing Wanga a Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, bDepartment of Thoracic Surgery, Fujian Provincial Hospital, Provincial Clinic College of Fujian Medical University, Fuzhou, cDepartment of Respiratory Medicine, Fujian Provincial Hospital, Provincial Clinic College of Fujian Medical University, Fuzhou, dDepartment of Thoracic Surgery, the Central Hospital of Wuhan, Wuhan, eDepartment of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China; f7KHÀUVWWZRDXWKRUVFRQWULEXWHGHTXDOO\WRWKLVZRUN
Key Words &\WRFKURPH3HSR[\JHQDVH-(SR[\HLFRVDWULHQRLFDFLGV/XQJLVFKHPLDUHSHUIXVLRQ LQMXU\2[LGDWLYHVWUHVV$SRSWRVLV Abstract Background: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acids to epoxyeicosatrienoic acids (EETs). EETs exert various biological effects, including antiLQÁDPPDWRU\ DQWLDSRSWRWLF SURSUROLIHUDWLRQ SURDQJLRJHQHVLV DQWLR[LGDWLRQ DQG DQWL ÀEURVLVHIIHFWV+RZHYHUOLWWOHLVNQRZQDERXWWKHUROHRI&
Cell Physiol Biochem 2014;33:1663-1680 DOI: 10.1159/000362950 Published online: May 16, 2014
© 2014 S. Karger AG, Basel www.karger.com/cpb
Chen et al.:April EETs07, and2014 Lung Ischemia/Reperfusion Injury Accepted: 1421-9778/14/0336-1663$39.50/0 This is an Open Access article licensed under the terms of the Creative Commons AttributionNonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Original Paper
CYP2J2 and EETs Protect against Oxidative Stress and Apoptosis in Vivo and in Vitro Following Lung Ischemia/Reperfusion Wenshu Chena,b,f Guanying Zhengc,f Shijiang Yangd Wei Pinga Xiangning Fua Ni Zhanga Dao Wen Wange Jianing Wanga a Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, bDepartment of Thoracic Surgery, Fujian Provincial Hospital, Provincial Clinic College of Fujian Medical University, Fuzhou, cDepartment of Respiratory Medicine, Fujian Provincial Hospital, Provincial Clinic College of Fujian Medical University, Fuzhou, dDepartment of Thoracic Surgery, the Central Hospital of Wuhan, Wuhan, eDepartment of Internal Medicine and Gene Therapy Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China; f7KHÀUVWWZRDXWKRUVFRQWULEXWHGHTXDOO\WRWKLVZRUN
Key Words &\WRFKURPH3HSR[\JHQDVH-(SR[\HLFRVDWULHQRLFDFLGV/XQJLVFKHPLDUHSHUIXVLRQ LQMXU\2[LGDWLYHVWUHVV$SRSWRVLV Abstract Background: Cytochrome P450 epoxygenase 2J2 (CYP2J2) metabolizes arachidonic acids to epoxyeicosatrienoic acids (EETs). EETs exert various biological effects, including antiLQÁDPPDWRU\ DQWLDSRSWRWLF SURSUROLIHUDWLRQ SURDQJLRJHQHVLV DQWLR[LGDWLRQ DQG DQWL ÀEURVLVHIIHFWV+RZHYHUOLWWOHLVNQRZQDERXWWKHUROHRI&
