HHS Public Access Author manuscript Author Manuscript
Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2016 November 01. Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 November ; 35(11): 2468–2477. doi:10.1161/ATVBAHA. 115.305724.
Residential Proximity to Major Roadways is Associated with Increased Levels of AC133+ Circulating Angiogenic Cells
Author Manuscript
Natasha DeJarnett, Ph.D., M.P.H.1,2,3, Ray Yeager, M.P.H.1,2, Daniel J. Conklin, Ph.D.1,3, Jongmin Lee, Ph.D.1,3, Timothy E. O'Toole, Ph.D.1,3, James McCracken, Ph.D.1,3, Wes Abplanalp, B.S.1,3, Sanjay Srivastava, Ph.D.1,3, Daniel W. Riggs, M.S.1,3, Ihab Hamzeh, M.D. 4, Stephen Wagner, M.D.3, Atul Chugh, M.D.1,3, Andrew DeFilippis, M.D., M.Sc.1,3,5, Tiffany Ciszewski, M.Ed.1,3, Brad Wyatt, D.M.D., M.P.H.1,3, Carrie Becher, M.P.H.3, Deirdre Higdon, A.P.R.N.3, Kenneth S. Ramos, M.D., Ph.D.6, David J. Tollerud, M.D., M.P.H.2, John A. Myers, Ph.D., M.S.P.H.7, Shesh N. Rai, Ph.D.1,8,9, Jasmit Shah, M.S.1,3, Nagma Zafar, M.D.1, Sathya S. Krishnasamy, M.D.1,10, Sumanth D. Prabhu, M.D.3,11, and Aruni Bhatnagar, Ph.D.1,3,6 1Diabetes
and Obesity Center, University of Louisville, Louisville, KY 40292
2Department
of Environmental and Occupational Health Sciences, University of Louisville, Louisville, KY 40292 3Institue
4Baylor
of Molecular Cardiology, University of Louisville, Louisville, KY 40292
College of Medicine, Houston, TX 77030
Author Manuscript
5Department
of Medicine, Johns Hopkins University, Baltimore, MD 21205
6Department
of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40292
7Department
of Pediatrics, University of Louisville, Louisville, KY 40292
8Department
of Bioinformatics and Biostatics, University of Louisville, Louisville, KY 40292
9Biostatistics
Shared Facility, JG Brown Cancer Center, University of Louisville, Louisville, KY
40292 10Division
of Endocrinology, Metabolism & Diabetes, University of Louisville, Louisville, KY 40292
11Division
of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL
35294
Author Manuscript
Abstract Objective—Previous studies have shown that residential proximity to a roadway is associated with increased cardiovascular disease (CVD) risk. Yet the nature of this association remains unclear, and its impact on individual CVD risk factors has not been assessed. The objective of this study was to determine whether residential proximity to roadways influences systemic inflammation and the levels of circulating angiogenic cells.
Address correspondence to Aruni Bhatnagar, Ph.D., Diabetes and Obesity Center, Delia Baxter Building, 580 S. Preston Street, Rm. 421F, Louisville, KY 40202. Phone: 502-852-5724. Fax: 502-852-3663.
[email protected]. CONFLICT OF INTEREST DISCLOSURES The authors declare that they have no actual or potential competing financial interests.
DeJarnett et al.
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Approach and Results—In a cross-sectional study, CVD risk factors, blood levels of Creactive protein (CRP), and 15 antigenically-defined circulating angiogenic cell populations were measured in participants (n=316) with moderate to high CVD risk. Attributes of roadways surrounding residential locations were assessed using Geographic Information Systems. Associations between road proximity and cardiovascular indices were analyzed using Generalized Linear Models. Close proximity (