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. . . Published ahead of Print

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Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle Craig Porter1,2, Paul T. Reidy3, Nisha Bhattarai1,2, Labros S. Sidossis1,2,4, and Blake B. Rasmussen3,5 1

Metabolism Unit, Shriners Hospitals for Children – Galveston, TX Department of Surgery, University of Texas Medical Branch, Galveston, TX 3 Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX 4 Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 5 Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX

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Accepted for Publication: 12 December 2014

Medicine & Science in Sports & Exercise® Published ahead of Print contains articles in unedited manuscript form that have been peer reviewed and accepted for publication. This manuscript will undergo copyediting, page composition, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered that could affect the content. Copyright © 2014 American College of Sports Medicine Copyright © 2014 by the American College of Sports Medicine. Unauthorized reproduction of this article is prohibited.

Medicine & Science in Sports & Exercise, Publish Ahead of Print DOI: 10.1249/MSS.0000000000000605

Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle

Craig Porter1,2, Paul T. Reidy3, Nisha Bhattarai1,2, Labros S. Sidossis1,2,4 and Blake B. Rasmussen3,5 1

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Rehabilitation Sciences, University of Texas Medical Branch, Galveston, TX

Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX

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Department of Surgery, University of Texas Medical Branch, Galveston, TX

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Metabolism Unit, Shriners Hospitals for Children – Galveston, TX

Department of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, TX

Corresponding author:

Metabolism Unit

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Craig Porter

Shriners Hospitals for Children 815 Market Street

Texas 77550

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Galveston

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Email: [email protected] Tel. 409-770-6670

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Fax: 409-770-6919

This work was supported by grants from the National Institutes of Health (RO1 AR049877 and P30 AG024832), and Shriners Hospitals for Children (84090). Study visits were conducted with the support of the Institute for Translational Sciences at the University of Texas Medical Branch, which is supported by a Clinical and Translational Science Award (UL1TR000071) from the National Center for Advancing Translational Sciences, National Institutes of Health. CP is supported by an Interdisciplinary Rehabilitation Research Postdoctoral Training Grant (H133P110012) from the National Institute for Disabilities and Rehabilitation Research and the Department of Education.

Copyright © 2014 by the American College of Sports Medicine. Unauthorized reproduction of this article is prohibited.

Conflict of Interest: None of the authors have any relevant conflicts of interest to disclose.

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Short title: Resistance exercise and muscle bioenergetics

Copyright © 2014 by the American College of Sports Medicine. Unauthorized reproduction of this article is prohibited.

Abstract Introduction: Loss of mitochondrial competency is associated with several chronic illnesses. Therefore, strategies that maintain or increase mitochondrial function will likely be of benefit in a number of clinical settings. Endurance exercise has long been known to increase mitochondrial function in skeletal muscle. Comparatively little is known regarding the impact of

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resistance exercise training on skeletal muscle mitochondrial respiratory function. Purpose: The purpose of the current study was to determine the impact of chronic resistance training on skeletal

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muscle mitochondrial respiratory capacity and function. Methods: Here, we studied the impact of a 12-week resistance exercise training program on skeletal muscle mitochondrial function in eleven young healthy men. Muscle biopsies were collected before and after the 12-week training program

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and mitochondrial respiratory capacity determined in permeabilized myofibers by high-resolution respirometry. Results: Resistance exercise training increased lean body mass and quadriceps muscle strength by 4 and 15%, respectively (P

Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle.

Loss of mitochondrial competency is associated with several chronic illnesses. Therefore, strategies that maintain or increase mitochondrial function ...
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