JOURNAL OF NEUROCHEMISTRY
| 2014 | 129 | 1035
D’Onofrio M., Cuomo L., Battaglia G., Ngomba R. T., Storto M., Kingston A. E., Orzil F., De Blasi A., Di Iorio P., Nicoletti F. and Bruno V. (2001) Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. J. Neurochem. Volume 78, Issue 3, pages 435-445, DOI: 10.1046/j.1471-4159.2001.00435.x (available through www.onlinelibrary.wiley.com). The above referenced article has been retracted by agreement between the Journal’s Chief Editor J€ org Schulz, John Wiley & Sons Ltd., and the following authors: F. Nicoletti, G. Battaglia, R.T. Ngomba, M. Storto, F. Orzi, A. De Blasi, P. Di Iorio, and V. Bruno. The authors M. D’Onofrio and L. Cuomo disagreed with the retraction. A. E. Kingston could not be tracked. The retraction has been agreed due to concerns the Editorial Office was notified about relating to Fig. 1b (upper left panel) and Fig. 7b. In Fig. 1b, the spleen band of the immunoblot looked cut and pasted. The author confirms that the blot had been cut and pasted to show that the antibody was working. Further concerns related to Fig. 7b in which the middle lane (NMDA+LY379268) looked cut and pasted. The authors concluded from the immunoblots of TGF-beta, from which four of five bands were shown in Fig. 7b (see figure), that the combination between NMDA and LY379268 enhanced TGFbeta1 levels in the striatum, and that ERK/PI3-kinase-mediated induction of TGF-beta contributes to the ability of metabotropic glutamate receptors to promote neuroprotection against excitotoxic lesions. The original Western blot is shown with the lanes that correspond to the published figure. The (NMDA+LY379268) lane shown in the published figure had been imported from a different blot, the original blot of which could not be tracked. The same held for the matching betaactin lanes for either blot. Although the authors provided evidence that the principal findings and conclusions were confirmed in other experiments, in the figure in question the difference between the bands appears stronger than is visible in the Western blot the remaining bands had been imported from.
doi: 10.1111/jnc.12688
The senior author apologises and acknowledges the individual who brought these problems to the attention of the Journal. Band numbering in Fig 7b
1
Band numbering in the original blot
1
5
2 3 4
5
4
6
7
2
8 9 10 11 12
Fig. 7b The figure shows the original immunoblot which parts of Fig. 7b of the retracted article were compiled from. The blot had been repeated twice. Lanes 1,6=Basal; 4,11= NMDA; Lane 1 of the original blot corresponds to lane 1 in Fig. 7b (Basal); Lane 11 of the original blot corresponds to lane 2 in Fig. 7b (NMDA); Lane 7 of the original blot corresponds to lane 4 in Fig. 7b (NMDA+LY379268+PD98059); Lane 5 of the original blot corresponds to lane 5 in Fig. 7b (NMDA+PD98059) Lane 3 of Fig. 7b was imported from the second blot (not available). The three NMDA + LY379268 lanes in the original blot (lanes 2, 3, 10) are clearly darker.
Reference D’Onofrio M., Cuomo L., Battaglia G., Ngomba R. T., Storto M., Kingston A. E., Orzi F., De Blasi A., Di Iorio P., Nicoletti F. and Bruno V. (2001) Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. J. Neurochem. 78, 435–445. DOI: 10.1046/j.1471-4159.2001.00435.x
Corrigendum notice on a related paper: J. Neurochem. 129, 1036. DOI: 10.1111/jnc.12689 This article corrects: D’Onofrio M., Arcella A., Bruno V., Ngomba R. T., Battaglia G., Lombari V., Ragona G., Calogero A. and Nicoletti F. (2003) Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells. J. Neurochem. 84, 1288–1295. DOI: 10.1046/j.1471-4159.2003. 01633.x
© 2014 International Society for Neurochemistry, J. Neurochem. (2014) 129, 1035
1035
| 2014 | 129 | 1035
D’Onofrio M., Cuomo L., Battaglia G., Ngomba R. T., Storto M., Kingston A. E., Orzil F., De Blasi A., Di Iorio P., Nicoletti F. and Bruno V. (2001) Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. J. Neurochem. Volume 78, Issue 3, pages 435-445, DOI: 10.1046/j.1471-4159.2001.00435.x (available through www.onlinelibrary.wiley.com). The above referenced article has been retracted by agreement between the Journal’s Chief Editor J€ org Schulz, John Wiley & Sons Ltd., and the following authors: F. Nicoletti, G. Battaglia, R.T. Ngomba, M. Storto, F. Orzi, A. De Blasi, P. Di Iorio, and V. Bruno. The authors M. D’Onofrio and L. Cuomo disagreed with the retraction. A. E. Kingston could not be tracked. The retraction has been agreed due to concerns the Editorial Office was notified about relating to Fig. 1b (upper left panel) and Fig. 7b. In Fig. 1b, the spleen band of the immunoblot looked cut and pasted. The author confirms that the blot had been cut and pasted to show that the antibody was working. Further concerns related to Fig. 7b in which the middle lane (NMDA+LY379268) looked cut and pasted. The authors concluded from the immunoblots of TGF-beta, from which four of five bands were shown in Fig. 7b (see figure), that the combination between NMDA and LY379268 enhanced TGFbeta1 levels in the striatum, and that ERK/PI3-kinase-mediated induction of TGF-beta contributes to the ability of metabotropic glutamate receptors to promote neuroprotection against excitotoxic lesions. The original Western blot is shown with the lanes that correspond to the published figure. The (NMDA+LY379268) lane shown in the published figure had been imported from a different blot, the original blot of which could not be tracked. The same held for the matching betaactin lanes for either blot. Although the authors provided evidence that the principal findings and conclusions were confirmed in other experiments, in the figure in question the difference between the bands appears stronger than is visible in the Western blot the remaining bands had been imported from.
doi: 10.1111/jnc.12688
The senior author apologises and acknowledges the individual who brought these problems to the attention of the Journal. Band numbering in Fig 7b
1
Band numbering in the original blot
1
5
2 3 4
5
4
6
7
2
8 9 10 11 12
Fig. 7b The figure shows the original immunoblot which parts of Fig. 7b of the retracted article were compiled from. The blot had been repeated twice. Lanes 1,6=Basal; 4,11= NMDA; Lane 1 of the original blot corresponds to lane 1 in Fig. 7b (Basal); Lane 11 of the original blot corresponds to lane 2 in Fig. 7b (NMDA); Lane 7 of the original blot corresponds to lane 4 in Fig. 7b (NMDA+LY379268+PD98059); Lane 5 of the original blot corresponds to lane 5 in Fig. 7b (NMDA+PD98059) Lane 3 of Fig. 7b was imported from the second blot (not available). The three NMDA + LY379268 lanes in the original blot (lanes 2, 3, 10) are clearly darker.
Reference D’Onofrio M., Cuomo L., Battaglia G., Ngomba R. T., Storto M., Kingston A. E., Orzi F., De Blasi A., Di Iorio P., Nicoletti F. and Bruno V. (2001) Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways. J. Neurochem. 78, 435–445. DOI: 10.1046/j.1471-4159.2001.00435.x
Corrigendum notice on a related paper: J. Neurochem. 129, 1036. DOI: 10.1111/jnc.12689 This article corrects: D’Onofrio M., Arcella A., Bruno V., Ngomba R. T., Battaglia G., Lombari V., Ragona G., Calogero A. and Nicoletti F. (2003) Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells. J. Neurochem. 84, 1288–1295. DOI: 10.1046/j.1471-4159.2003. 01633.x
© 2014 International Society for Neurochemistry, J. Neurochem. (2014) 129, 1035
1035
