HHS Public Access Author manuscript Author Manuscript
J Magn Reson Imaging. Author manuscript; available in PMC 2017 May 01. Published in final edited form as: J Magn Reson Imaging. 2016 May ; 43(5): 1132–1139. doi:10.1002/jmri.25068.
Right Ventricular Strain by MR Quantitatively Identifies Regional Dysfunction in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Author Manuscript
Davis M. Vigneault, BS1,2,3,†, Anneline S.J.M. te Riele, MD4,5,†, Cynthia A. James, PhD4, Stefan L. Zimmerman, MD6, Mariana Selwaness, PhD1,7, Brittney Murray, MS4, Crystal Tichnell, MGC, Michael Tee1,2, J. Alison Noble, PhD2, Hugh Calkins, MD4, Harikrishna Tandri, MD4, and David A. Bluemke, MD, PhD1 1Radiology
and Imaging Sciences - National Institutes of Health Clinical Center, Bethesda, MD, USA of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, United Kingdom 3Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA 4Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA 5Department of Medicine, Division of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands 6Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, USA 7Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands 2Department
Author Manuscript
Abstract Purpose—Analysis of regional wall motion of the right ventricle (RV) is primarily qualitative with large interobserver variation in clinical practice. Thus the purpose of this study was to use feature tracking to analyze regional wall motion abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC).
Author Manuscript
Materials and Methods—We enrolled 110 subjects (39 overt ARVC [mutation+/phenotype+] (35.5%), 40 preclinical ARVC [mutation+/phenotype–] (36.3%), and 31 control subjects (28.2%)). Cine steady state free precession cardiac MR was performed with temporal resolution ≤40 msec in the horizontal long axis (HLA), axial, and short axis (SA) directions. Regional strain was analyzed using feature tracking software and reproducibility was assessed via intraclass correlation coefficient. Dunnett's test was used in univariate analysis for comparisons to control subjects; cumulative odds logistic regression was used for minimally and fully adjusted multivariate models. Results—Strain was significantly impaired in overt ARVC compared to control subjects both globally (p500 PVCs/24 hrs Structural criteria Major Minor TFC fulfillment: number of criteria (median)
9 (23)
0 (0)
-
21/32 (66)
2/35 (6)
-
23 (59)
0 (0)
-
16 (41)
0 (0)
-
7 (18)
0 (0)
-
6 (IQR 5-7)
2 (IQR 2-3)
-
*p
J Magn Reson Imaging. Author manuscript; available in PMC 2017 May 01. Published in final edited form as: J Magn Reson Imaging. 2016 May ; 43(5): 1132–1139. doi:10.1002/jmri.25068.
Right Ventricular Strain by MR Quantitatively Identifies Regional Dysfunction in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Author Manuscript
Davis M. Vigneault, BS1,2,3,†, Anneline S.J.M. te Riele, MD4,5,†, Cynthia A. James, PhD4, Stefan L. Zimmerman, MD6, Mariana Selwaness, PhD1,7, Brittney Murray, MS4, Crystal Tichnell, MGC, Michael Tee1,2, J. Alison Noble, PhD2, Hugh Calkins, MD4, Harikrishna Tandri, MD4, and David A. Bluemke, MD, PhD1 1Radiology
and Imaging Sciences - National Institutes of Health Clinical Center, Bethesda, MD, USA of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, United Kingdom 3Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA 4Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA 5Department of Medicine, Division of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands 6Department of Radiology, Johns Hopkins Hospital, Baltimore, MD, USA 7Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands 2Department
Author Manuscript
Abstract Purpose—Analysis of regional wall motion of the right ventricle (RV) is primarily qualitative with large interobserver variation in clinical practice. Thus the purpose of this study was to use feature tracking to analyze regional wall motion abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC).
Author Manuscript
Materials and Methods—We enrolled 110 subjects (39 overt ARVC [mutation+/phenotype+] (35.5%), 40 preclinical ARVC [mutation+/phenotype–] (36.3%), and 31 control subjects (28.2%)). Cine steady state free precession cardiac MR was performed with temporal resolution ≤40 msec in the horizontal long axis (HLA), axial, and short axis (SA) directions. Regional strain was analyzed using feature tracking software and reproducibility was assessed via intraclass correlation coefficient. Dunnett's test was used in univariate analysis for comparisons to control subjects; cumulative odds logistic regression was used for minimally and fully adjusted multivariate models. Results—Strain was significantly impaired in overt ARVC compared to control subjects both globally (p500 PVCs/24 hrs Structural criteria Major Minor TFC fulfillment: number of criteria (median)
9 (23)
0 (0)
-
21/32 (66)
2/35 (6)
-
23 (59)
0 (0)
-
16 (41)
0 (0)
-
7 (18)
0 (0)
-
6 (IQR 5-7)
2 (IQR 2-3)
-
*p
