Author's Accepted Manuscript
Risk factors and causes of sudden non-cardiac death: a nationwide cohort study in Denmark Bjarke Risgaard MD, Thomas Hadberg Lynge BM, Mads Wissenberg MD, Reza Jabbari MD, Charlotte Glinge BM, Gunnar Hilmar Gislason MD, DMSc, Stig Haunsø MD, DMSc, Bo Gregers Winkel MD, PH.D., Jacob Tfelt-Hansen MD, DMSc www.elsevier.com/locate/buildenv
PII: DOI: Reference:
S1547-5271(15)00074-0 http://dx.doi.org/10.1016/j.hrthm.2015.01.024 HRTHM6095
To appear in:
Heart Rhythm
Cite this article as: Bjarke Risgaard MD, Thomas Hadberg Lynge BM, Mads Wissenberg MD, Reza Jabbari MD, Charlotte Glinge BM, Gunnar Hilmar Gislason MD, DMSc, Stig Haunsø MD, DMSc, Bo Gregers Winkel MD, PH.D., Jacob Tfelt-Hansen MD, DMSc, Risk factors and causes of sudden non-cardiac death: a nationwide cohort study in Denmark, Heart Rhythm, http://dx.doi.org/10.1016/j.hrthm.2015.01.024 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Risk factors and causes of sudden non-cardiac death: a nationwide cohort study in Denmark
Short title: Sudden non-cardiac death Bjarke Risgaard, MD12*; Thomas Hadberg Lynge, BM12; Mads Wissenberg, MD3; Reza Jabbari, MD12; Charlotte Glinge, BM12; Gunnar Hilmar Gislason, MD, DMSc34; Stig Haunsø, MD, DMSc125; Bo Gregers Winkel, MD, PHD12; Jacob Tfelt-Hansen, MD, DMSc125.
Affiliations 1Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Copenhagen, Denmark; 2Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 3Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark; 4The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. 5Department of Medicine and Surgery, University of Copenhagen, Copenhagen, Denmark
Word count: 4,908
Corresponding author: *
Corresponding author: Bjarke Risgaard, MD. Address for correspondence: Laboratory of Molecular Cardiology, The
Heart Centre, Copenhagen University Hospital, Rigshospitalet, 9312, Juliane Maries Vej 20, 2100 Copenhagen Ø. Tel: (+45) 35 45 65 01 Fax: (+45) 35 45 65 00 Email: [email protected]
1
ABSTRACT Background: Upon the performance of an autopsy, sudden deaths may be divided into: 1) sudden cardiac deaths and 2) sudden non-cardiac deaths (SNCDs). Families of SNCD victims should not be followed as a means of searching for cardiac disease. Objective: To report the risk factors and causes of SNCD. Methods and results: We conducted a retrospective, nationwide study including all deaths between 20002006 of individuals aged 1-35 years and all deaths between 2007-2009 of individuals aged 1-49 years. Two physicians identified all sudden death cases through review of death certificates. Autopsy reports were collected. A multivariable logistic regression model was used to identify both clinical characteristics and risk factors associated with SNCD. We identified 1,039 autopsied cases of sudden death, of which 286 (28%) deaths were classified as SNCD. The median age in the SNCD death population was 32 years. Increasing age was inversely associated with SNCD (OR 0.93 95% CI: 0.87-0.98). Female gender, in-hospital location, and the absence of cardiac comorbidities were positively associated with SNCD (OR 1.7 95% CI: 1.3-2.3; OR 3.0 95% CI: 2.0-4.4 and OR 4.3 95% CI: 2.5-7.4, respectively). The most common causes of SNCD were pulmonary diseases (n=115, 40%). Conclusions: Sudden death among individuals
Risk factors and causes of sudden non-cardiac death: a nationwide cohort study in Denmark Bjarke Risgaard MD, Thomas Hadberg Lynge BM, Mads Wissenberg MD, Reza Jabbari MD, Charlotte Glinge BM, Gunnar Hilmar Gislason MD, DMSc, Stig Haunsø MD, DMSc, Bo Gregers Winkel MD, PH.D., Jacob Tfelt-Hansen MD, DMSc www.elsevier.com/locate/buildenv
PII: DOI: Reference:
S1547-5271(15)00074-0 http://dx.doi.org/10.1016/j.hrthm.2015.01.024 HRTHM6095
To appear in:
Heart Rhythm
Cite this article as: Bjarke Risgaard MD, Thomas Hadberg Lynge BM, Mads Wissenberg MD, Reza Jabbari MD, Charlotte Glinge BM, Gunnar Hilmar Gislason MD, DMSc, Stig Haunsø MD, DMSc, Bo Gregers Winkel MD, PH.D., Jacob Tfelt-Hansen MD, DMSc, Risk factors and causes of sudden non-cardiac death: a nationwide cohort study in Denmark, Heart Rhythm, http://dx.doi.org/10.1016/j.hrthm.2015.01.024 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Risk factors and causes of sudden non-cardiac death: a nationwide cohort study in Denmark
Short title: Sudden non-cardiac death Bjarke Risgaard, MD12*; Thomas Hadberg Lynge, BM12; Mads Wissenberg, MD3; Reza Jabbari, MD12; Charlotte Glinge, BM12; Gunnar Hilmar Gislason, MD, DMSc34; Stig Haunsø, MD, DMSc125; Bo Gregers Winkel, MD, PHD12; Jacob Tfelt-Hansen, MD, DMSc125.
Affiliations 1Danish National Research Foundation Centre for Cardiac Arrhythmia (DARC), University of Copenhagen, Copenhagen, Denmark; 2Laboratory of Molecular Cardiology, Department of Cardiology, The Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; 3Department of Cardiology, Copenhagen University Hospital, Gentofte, Denmark; 4The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. 5Department of Medicine and Surgery, University of Copenhagen, Copenhagen, Denmark
Word count: 4,908
Corresponding author: *
Corresponding author: Bjarke Risgaard, MD. Address for correspondence: Laboratory of Molecular Cardiology, The
Heart Centre, Copenhagen University Hospital, Rigshospitalet, 9312, Juliane Maries Vej 20, 2100 Copenhagen Ø. Tel: (+45) 35 45 65 01 Fax: (+45) 35 45 65 00 Email: [email protected]
1
ABSTRACT Background: Upon the performance of an autopsy, sudden deaths may be divided into: 1) sudden cardiac deaths and 2) sudden non-cardiac deaths (SNCDs). Families of SNCD victims should not be followed as a means of searching for cardiac disease. Objective: To report the risk factors and causes of SNCD. Methods and results: We conducted a retrospective, nationwide study including all deaths between 20002006 of individuals aged 1-35 years and all deaths between 2007-2009 of individuals aged 1-49 years. Two physicians identified all sudden death cases through review of death certificates. Autopsy reports were collected. A multivariable logistic regression model was used to identify both clinical characteristics and risk factors associated with SNCD. We identified 1,039 autopsied cases of sudden death, of which 286 (28%) deaths were classified as SNCD. The median age in the SNCD death population was 32 years. Increasing age was inversely associated with SNCD (OR 0.93 95% CI: 0.87-0.98). Female gender, in-hospital location, and the absence of cardiac comorbidities were positively associated with SNCD (OR 1.7 95% CI: 1.3-2.3; OR 3.0 95% CI: 2.0-4.4 and OR 4.3 95% CI: 2.5-7.4, respectively). The most common causes of SNCD were pulmonary diseases (n=115, 40%). Conclusions: Sudden death among individuals
