MAJOR ARTICLE
Risk of Pneumococcal Disease in Children With Chronic Medical Conditions in the Era of Pneumococcal Conjugate Vaccine Downloaded from http://cid.oxfordjournals.org/ at University Library, University of Illinois at Chicago on October 30, 2014
Stephen I. Pelton,1,2 Derek Weycker,3 Raymond A. Farkouh,4 David R. Strutton,4 Kimberly M. Shea,1 and John Edelsberg3 1
Schools of Medicine and Public Health, Boston University, 2Boston Medical Center, and 3Policy Analysis Inc, Brookline, Massachusetts; and 4Pfizer Inc, Collegeville, Pennsylvania
Background. In the current era of universal immunization of young children with pneumococcal conjugate vaccine, it is unclear whether the high risk ratios for pneumococcal disease previously attributed to specified chronic conditions have persisted. In addition, further analysis of pneumococcal disease risk may clarify whether certain chronic conditions that currently are not specified as significantly increasing the risk of pneumococcal disease should be so considered. Methods. We conducted a retrospective cohort analysis utilizing healthcare claims data from the period 2007–2010 to compare rates of pneumococcal disease among children
Risk of Pneumococcal Disease in Children With Chronic Medical Conditions in the Era of Pneumococcal Conjugate Vaccine Downloaded from http://cid.oxfordjournals.org/ at University Library, University of Illinois at Chicago on October 30, 2014
Stephen I. Pelton,1,2 Derek Weycker,3 Raymond A. Farkouh,4 David R. Strutton,4 Kimberly M. Shea,1 and John Edelsberg3 1
Schools of Medicine and Public Health, Boston University, 2Boston Medical Center, and 3Policy Analysis Inc, Brookline, Massachusetts; and 4Pfizer Inc, Collegeville, Pennsylvania
Background. In the current era of universal immunization of young children with pneumococcal conjugate vaccine, it is unclear whether the high risk ratios for pneumococcal disease previously attributed to specified chronic conditions have persisted. In addition, further analysis of pneumococcal disease risk may clarify whether certain chronic conditions that currently are not specified as significantly increasing the risk of pneumococcal disease should be so considered. Methods. We conducted a retrospective cohort analysis utilizing healthcare claims data from the period 2007–2010 to compare rates of pneumococcal disease among children
