ONCOLOGY LETTERS 11: 484-490, 2016
484
Resveratrol suppresses human glioblastoma cell migration and invasion via activation of RhoA/ROCK signaling pathway WEI XIONG1,2, ANAN YIN1, XINGGANG MAO1, WEI ZHANG1, HUIYONG HUANG1 and XIANG ZHANG1 1
Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Fourth Military Medical University, Xi'an, Shaanxi 710032; 2Trauma Centre, The 196th Hospital of PLA, Zhanjiang, Guangdong 524000, P.R. China Received November 1, 2014; Accepted September 17, 2015 DOI: 10.3892/ol.2015.3888
Abstract. Numerous studies have demonstrated that resveratrol has a potential use in cancer prevention and treatment. However, the effects of resveratrol on cancer cell motility and invasiveness remain unclear. The current study aimed to examine the effects of resveratrol on cell migration and invasion in human glioblastoma cells, and to explore the underlying molecular mechanisms. In wound‑healing and Matrigel transwell assays, resveratrol was found to significantly inhibit the migration and invasion of U87MG, T98G and U251 glioblastoma cells in vitro. Results from western blot analysis and gelatin zymography revealed that resveratrol also suppressed the expression and activity of matrix metalloproteinase 2 (MMP‑2; P
484
Resveratrol suppresses human glioblastoma cell migration and invasion via activation of RhoA/ROCK signaling pathway WEI XIONG1,2, ANAN YIN1, XINGGANG MAO1, WEI ZHANG1, HUIYONG HUANG1 and XIANG ZHANG1 1
Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Fourth Military Medical University, Xi'an, Shaanxi 710032; 2Trauma Centre, The 196th Hospital of PLA, Zhanjiang, Guangdong 524000, P.R. China Received November 1, 2014; Accepted September 17, 2015 DOI: 10.3892/ol.2015.3888
Abstract. Numerous studies have demonstrated that resveratrol has a potential use in cancer prevention and treatment. However, the effects of resveratrol on cancer cell motility and invasiveness remain unclear. The current study aimed to examine the effects of resveratrol on cell migration and invasion in human glioblastoma cells, and to explore the underlying molecular mechanisms. In wound‑healing and Matrigel transwell assays, resveratrol was found to significantly inhibit the migration and invasion of U87MG, T98G and U251 glioblastoma cells in vitro. Results from western blot analysis and gelatin zymography revealed that resveratrol also suppressed the expression and activity of matrix metalloproteinase 2 (MMP‑2; P
