Acta Clinica Belgica International Journal of Clinical and Laboratory Medicine
ISSN: 1784-3286 (Print) 2295-3337 (Online) Journal homepage: http://www.tandfonline.com/loi/yacb20
Routine Laboratory Tests And The Evaluation Of The Function Of The Thyroid Gland In Thyrotoxicosis. An Ordinator Assisted Study On A Belgian Population R. Rubens, F. Comhaire & J. van Egmond To cite this article: R. Rubens, F. Comhaire & J. van Egmond (1975) Routine Laboratory Tests And The Evaluation Of The Function Of The Thyroid Gland In Thyrotoxicosis. An Ordinator Assisted Study On A Belgian Population, Acta Clinica Belgica, 30:5, 392-397, DOI: 10.1080/17843286.1975.11717028 To link to this article: http://dx.doi.org/10.1080/17843286.1975.11717028
Published online: 21 May 2016.
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Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=yacb20 Download by: [Australian Catholic University]
Date: 20 August 2017, At: 04:51
392
ROUTINE LABORATORY TESTS AND THE EVALUATION OF THE FUNCTION OF THE THYROID GLAND IN THYROTOXICOSIS. AN ORDINATOR ASSISTED STUDY ON A BELGIAN POPULATION
Downloaded by [Australian Catholic University] at 04:51 20 August 2017
R. RUBENS*. F. COMHAIRE*. J . van EGMOND**
INTRODUCTION
A survey of a Belgian population suffering from thyrotoxicosis was performed. The clinical and epidemiological aspects were reported in a previous communication (4). This paper will try to assess the value of routine biochemical parameters and functional tests of the thyroid gland. The more specific parameters such as protein bound iodine and hormone determinations were reviewed in another paper (5). Our aim was to determine whether routine biochemical parameters showed a significant difference between hyperthyroid and nonhyperthyroid patients. A group of thyrotoxic patients, consisting of 130 cases of Graves disease and 30 cases of toxic adenoma, was compared with a group of 36 patients suffering from so called "Non-hyperthyroid" disease (4).
calcium, phosphorus and alkaline phosphatase were measured by automated methods in the routine laboratory of our department (Dir. Prof. Dr. R.J . Wieme). The basal metabolic rate (B.M .R.) was measured by a Sanborn respiratory apparatus using a normogram provided by the same company, to assess, the percentage above or below normal. Achilles reflex time was assessed by a photomotograph connected to an electrocardiographic apparatus . Protein bound iodine was measured by a technicon auto-analyzer method. The T 3 test was performed using the Hamolsky technique (8) in the department of radiotherapeutics (Dir. Prof. Dr. P.M. Van Vaerenbergh). Statistical analysis was carried out using the chi-square test using a Yates correction whenever appropriate. RESULTS AND DISCUSSION
METHODS
A) Routine biochemical parameters
Prior to any therapy, several biochemical and metabolic parameters were measured in each patient. Serum glutaminic oxalacetic transaminase (S.G.O.T.), serum glutaminic pyruvic transaminase (S.G.P.T.), serum creatinine, cholesterol,
l. S.G.O.T. and S.G.P.T.
* Dept. of Medicine, Section of Endocrinology and Metabolic Diseases (Head Prof. Dr. A. Vermeulen) State University of Gent, Belgium. ** Dept. of Medical Informatics (Head Prof. Dr. Wieme) State University of Gent, Belgium. Acta C/inica Be/gica, 30. 5 (19 75)
As can be seen in table I no difference in occurrence of increased values could be observed in S.G.O.T. The S.G.P.T. was however puzzling; a difference being observed between nonhyperthyroid and hyperthyroid patients. The possibility of the disturbed hepatocellular function in Graves Disease is well documented (l, 3, 16, 18). The etiology of this phenomenon is however still unclear. Some authors favour an intrinsic · hepatocellular dysfunction whereas others claim a circulatory disturbance in the liv-
LABORATORY TESTS IN THYROTOXICOSIS
393 Table I
Biochemical parameters % of pathological values Limit•
Downloaded by [Australian Catholic University] at 04:51 20 August 2017
S.G .O .T. S.G.P.T . Alk a line Ph os ph atase Ca lc ium C rea tinine Ph os ph o ru s
> > > > >
ISSN: 1784-3286 (Print) 2295-3337 (Online) Journal homepage: http://www.tandfonline.com/loi/yacb20
Routine Laboratory Tests And The Evaluation Of The Function Of The Thyroid Gland In Thyrotoxicosis. An Ordinator Assisted Study On A Belgian Population R. Rubens, F. Comhaire & J. van Egmond To cite this article: R. Rubens, F. Comhaire & J. van Egmond (1975) Routine Laboratory Tests And The Evaluation Of The Function Of The Thyroid Gland In Thyrotoxicosis. An Ordinator Assisted Study On A Belgian Population, Acta Clinica Belgica, 30:5, 392-397, DOI: 10.1080/17843286.1975.11717028 To link to this article: http://dx.doi.org/10.1080/17843286.1975.11717028
Published online: 21 May 2016.
Submit your article to this journal
View related articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=yacb20 Download by: [Australian Catholic University]
Date: 20 August 2017, At: 04:51
392
ROUTINE LABORATORY TESTS AND THE EVALUATION OF THE FUNCTION OF THE THYROID GLAND IN THYROTOXICOSIS. AN ORDINATOR ASSISTED STUDY ON A BELGIAN POPULATION
Downloaded by [Australian Catholic University] at 04:51 20 August 2017
R. RUBENS*. F. COMHAIRE*. J . van EGMOND**
INTRODUCTION
A survey of a Belgian population suffering from thyrotoxicosis was performed. The clinical and epidemiological aspects were reported in a previous communication (4). This paper will try to assess the value of routine biochemical parameters and functional tests of the thyroid gland. The more specific parameters such as protein bound iodine and hormone determinations were reviewed in another paper (5). Our aim was to determine whether routine biochemical parameters showed a significant difference between hyperthyroid and nonhyperthyroid patients. A group of thyrotoxic patients, consisting of 130 cases of Graves disease and 30 cases of toxic adenoma, was compared with a group of 36 patients suffering from so called "Non-hyperthyroid" disease (4).
calcium, phosphorus and alkaline phosphatase were measured by automated methods in the routine laboratory of our department (Dir. Prof. Dr. R.J . Wieme). The basal metabolic rate (B.M .R.) was measured by a Sanborn respiratory apparatus using a normogram provided by the same company, to assess, the percentage above or below normal. Achilles reflex time was assessed by a photomotograph connected to an electrocardiographic apparatus . Protein bound iodine was measured by a technicon auto-analyzer method. The T 3 test was performed using the Hamolsky technique (8) in the department of radiotherapeutics (Dir. Prof. Dr. P.M. Van Vaerenbergh). Statistical analysis was carried out using the chi-square test using a Yates correction whenever appropriate. RESULTS AND DISCUSSION
METHODS
A) Routine biochemical parameters
Prior to any therapy, several biochemical and metabolic parameters were measured in each patient. Serum glutaminic oxalacetic transaminase (S.G.O.T.), serum glutaminic pyruvic transaminase (S.G.P.T.), serum creatinine, cholesterol,
l. S.G.O.T. and S.G.P.T.
* Dept. of Medicine, Section of Endocrinology and Metabolic Diseases (Head Prof. Dr. A. Vermeulen) State University of Gent, Belgium. ** Dept. of Medical Informatics (Head Prof. Dr. Wieme) State University of Gent, Belgium. Acta C/inica Be/gica, 30. 5 (19 75)
As can be seen in table I no difference in occurrence of increased values could be observed in S.G.O.T. The S.G.P.T. was however puzzling; a difference being observed between nonhyperthyroid and hyperthyroid patients. The possibility of the disturbed hepatocellular function in Graves Disease is well documented (l, 3, 16, 18). The etiology of this phenomenon is however still unclear. Some authors favour an intrinsic · hepatocellular dysfunction whereas others claim a circulatory disturbance in the liv-
LABORATORY TESTS IN THYROTOXICOSIS
393 Table I
Biochemical parameters % of pathological values Limit•
Downloaded by [Australian Catholic University] at 04:51 20 August 2017
S.G .O .T. S.G.P.T . Alk a line Ph os ph atase Ca lc ium C rea tinine Ph os ph o ru s
> > > > >
