Oral Maxillofac Surg DOI 10.1007/s10006-015-0502-9
ORIGINAL ARTICLE
Safety of adjunct pre-emptive intravenous tramadol with midazolam sedation for third molar surgery Lars B. Eriksson 1 & Åke Tegelberg 2,3
Received: 7 December 2014 / Accepted: 20 April 2015 # Springer-Verlag Berlin Heidelberg 2015
Abstract Purpose The purpose of this study was to evaluate patient safety, in terms of adverse events, alterations in blood pressure or oxygen saturation (SpO2) in two routine sedation procedures, with and without intravenous analgesia. Methods Patients referred for surgical removal of mandibular third molars were treated in a randomized, controlled, singleblinded procedure. Eighty-seven men and women, aged 18 to 44 years, were allotted to either of two treatment groups, midazolam + tramadol (M + T) and midazolam + saline (M + S) or to a control group (C), given no sedation. Results Tramadol at 1 mg/kg body weight resulted in a higher frequency of oxygen desaturation (SpO2
ORIGINAL ARTICLE
Safety of adjunct pre-emptive intravenous tramadol with midazolam sedation for third molar surgery Lars B. Eriksson 1 & Åke Tegelberg 2,3
Received: 7 December 2014 / Accepted: 20 April 2015 # Springer-Verlag Berlin Heidelberg 2015
Abstract Purpose The purpose of this study was to evaluate patient safety, in terms of adverse events, alterations in blood pressure or oxygen saturation (SpO2) in two routine sedation procedures, with and without intravenous analgesia. Methods Patients referred for surgical removal of mandibular third molars were treated in a randomized, controlled, singleblinded procedure. Eighty-seven men and women, aged 18 to 44 years, were allotted to either of two treatment groups, midazolam + tramadol (M + T) and midazolam + saline (M + S) or to a control group (C), given no sedation. Results Tramadol at 1 mg/kg body weight resulted in a higher frequency of oxygen desaturation (SpO2
