Accepted Manuscript Serum Ferritin Predicts Early Mortality In Patients With Decompensated Cirrhosis Rakhi Maiwall, Suman Kumar, A K Chaudhary, Jaswinder Maras, Zeeshan Wani, Chandan Kumar, A. Rastogi, C. Bihari, Chitranshu Vashisht, S K Sarin PII: DOI: Reference:

S0168-8278(14)00208-6 http://dx.doi.org/10.1016/j.jhep.2014.03.027 JHEPAT 5092

To appear in:

Journal of Hepatology

Received Date: Revised Date: Accepted Date:

18 June 2013 5 March 2014 13 March 2014

Please cite this article as: Maiwall, R., Kumar, S., Chaudhary, A.K., Maras, J., Wani, Z., Kumar, C., Rastogi, A., Bihari, C., Vashisht, C., Sarin, S.K., Serum Ferritin Predicts Early Mortality In Patients With Decompensated Cirrhosis, Journal of Hepatology (2014), doi: http://dx.doi.org/10.1016/j.jhep.2014.03.027

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SERUM FERRITIN PREDICTS EARLY MORTALITY IN PATIENTS WITH DECOMPENSATED CIRRHOSIS

Rakhi Maiwall1, Suman Kumar3, A K Chaudhary1, Jaswinder Maras4, Zeeshan Wani1, Chandan Kumar1, A. Rastogi2, C. Bihari,2 Chitranshu Vashisht1, S K Sarin1. 1

Department of Hepatology, Institute of liver and biliary sciences, 2Department of Pathology,

Institute of liver and biliary sciences, New Delhi, 3Department of Clinical Hematology, Command Hospital [Eastern Command], Kolkata, 4Department of Research, Institute of liver and biliary sciences

Key words: Decompensated cirrhosis, portal hypertension, ferritin, mortality, Hyperferritinemia Footnotes

Contact information: Corresponding authorDr. S.K. Sarin, M.D., D.M., F.N.A.Sc. Professor and Head, Department of Hepatology Institute of Liver and Biliary Sciences (ILBS)

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D1,Vasant Kunj, NewDelhi, 110070, India Fax: 310-206-8766. E-mail: [email protected]

Abbreviations: ALT,

Alanine aminotransferase; NAFLD,

Non-alcoholic

fatty liver

disease; DNA,

Deoxyribonucleic acid; MELD, Model for End Stage Liver Disease; CTP Child Turcott Pugh; HCC, Hepatocellular carcinoma; HVPG, Hepatic Venous Pressure Gradient; NASH, NonAlcoholic steatohepatitis; HRS, Hepato Renal Syndrome; SBP, Spontaneous Bacterial Peritonitis; TS, Transferrin saturation; INR, International normalized ratio; OLT, Orthotopic liver transplantation

Financial support: No financial assistance was taken for this study Potential conflict of interest: Nothing to report Word count: Abstract: 246 Manuscript: 4794

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ABSTRACT Background and Aim: Serum ferritin is a known marker of hepatic necro-inflammation and has been studied to predict 1 year mortality and post-transplant survival in decompensated cirrhotics. However, there are no studies evaluating ferritin as a predictor of early mortality. We investigated whether serum ferritin levels could predict 15 day and 30 day mortality in patients with decompensated cirrhosis. Patients and Methods: 318 patients with decompensated cirrhosis were included. Results: Patients of decompensated cirrhosis [257 males, mean age of 51 [±13] years, were followed for a median of 31 days. Serum ferritin levels were significantly different between survivors and non-survivors [p

Serum ferritin predicts early mortality in patients with decompensated cirrhosis.

Serum ferritin is a known marker of hepatic necro-inflammation and has been studied to predict 1 year mortality and post-transplant survival in decomp...
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