original article Wien Klin Wochenschr (2014) 126:727–733 DOI 10.1007/s00508-014-0612-7
Serum H-FABP levels in patients with hypothyroidism Fahri Gunes · Mehmet Asik · Ahmet Temiz · Ahmet Vural · Hacer Sen · Emine Binnetoglu · Neslihan Bozkurt · Zeliha Tekeli · Gokhan Erbag · Kubilay Ukinc · Erdem Akbal
Received: 25 February 2014 / Accepted: 29 August 2014 / Published online: 19 September 2014 © Springer-Verlag Wien 2014
Summary Objective Hypothyroidism (HT) has an increased risk for cardiovascular mortality and morbidity due to increased atherosclerosis. Heart-type fatty acid binding protein (H-FABP) is abundant in the cytosol of cardiomyocytes, and transports fatty acids into these cells. Although H-FABP has been shown to increase in several atherosclerotic and inflammatory conditions, there is no literature data indicating an alteration in other atherosclerotic processes such as HT. Material and methods A total of 39 patients with subclinical hypothyroidism (SCH), 26 patients with overt F. Gunes () Department of Internal Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey e-mail: [email protected] F. Gunes · H. Sen · E. Binnetoglu · N. Bozkurt · Z. Tekeli · G. Erbag Departments of General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey M. Asik · K. Ukinc Departments of Endocrinology and Metabolism, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
hypothyroidism (OH), and 29 healthy subjects were enrolled in this study. Carotid artery intima media thickness (CIMT) was measured by high resolution B mode ultrasonography. H-FABP levels, thyroid function test, and biochemical tests of all subjects were measured. The associations between H-FABP and thyroid test and CIMT were examined with correlation and regression analysis. Results OH patients had higher H-FABP levels (mean, 6.18 ± 3.08 ng/mL) than both the SCH (mean, 3.81 ± 2.16 ng/mL) and the controls (mean, 2.12 ± 1.27 ng/ mL) (P
Serum H-FABP levels in patients with hypothyroidism Fahri Gunes · Mehmet Asik · Ahmet Temiz · Ahmet Vural · Hacer Sen · Emine Binnetoglu · Neslihan Bozkurt · Zeliha Tekeli · Gokhan Erbag · Kubilay Ukinc · Erdem Akbal
Received: 25 February 2014 / Accepted: 29 August 2014 / Published online: 19 September 2014 © Springer-Verlag Wien 2014
Summary Objective Hypothyroidism (HT) has an increased risk for cardiovascular mortality and morbidity due to increased atherosclerosis. Heart-type fatty acid binding protein (H-FABP) is abundant in the cytosol of cardiomyocytes, and transports fatty acids into these cells. Although H-FABP has been shown to increase in several atherosclerotic and inflammatory conditions, there is no literature data indicating an alteration in other atherosclerotic processes such as HT. Material and methods A total of 39 patients with subclinical hypothyroidism (SCH), 26 patients with overt F. Gunes () Department of Internal Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey e-mail: [email protected] F. Gunes · H. Sen · E. Binnetoglu · N. Bozkurt · Z. Tekeli · G. Erbag Departments of General Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey M. Asik · K. Ukinc Departments of Endocrinology and Metabolism, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey
hypothyroidism (OH), and 29 healthy subjects were enrolled in this study. Carotid artery intima media thickness (CIMT) was measured by high resolution B mode ultrasonography. H-FABP levels, thyroid function test, and biochemical tests of all subjects were measured. The associations between H-FABP and thyroid test and CIMT were examined with correlation and regression analysis. Results OH patients had higher H-FABP levels (mean, 6.18 ± 3.08 ng/mL) than both the SCH (mean, 3.81 ± 2.16 ng/mL) and the controls (mean, 2.12 ± 1.27 ng/ mL) (P
