1293 that positive numbers indicate improvement on naloxone relative to saline, the mean naloxone effect on B.P.R.s. at 15 min was z0-56±1’76 and at 75 min it was 1-11±2-41, clearly insignificant differences. Thus, a major acute effect of naloxone on general psychopathology in schizophrenia seems unlikely. Most of our patients had minimal ratings for hallucinations so no conclusions can be drawn about the effect of naloxone on this symptom. Naloxone treatment, compared with saline treatment, caused a small but statistically significant increase in correct responses on the C.P.T. Two patients did not differ in performance between saline and naloxone, one did worse after naloxso

seven improved after naloxone Wilcoxon matched-pairs signed-ranks test).

one, while

D. S. S.T. scores

(two-tailed p