Kalfon et al. Critical Care (2015) 19:153 DOI 10.1186/s13054-015-0851-7
RESEARCH
Open Access
Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients Pierre Kalfon1*, Yannick Le Manach2, Carole Ichai3, Nicolas Bréchot4, Raphaël Cinotti5, Pierre-François Dequin6, Béatrice Riu-Poulenc7, Philippe Montravers8, Djilalli Annane9, Hervé Dupont10, Michel Sorine11, Bruno Riou12,13 and on behalf of the CGAO-REA Study Group
Abstract Introduction: In a randomized controlled trial comparing tight glucose control with a computerized decision support system and conventional protocols (post hoc analysis), we tested the hypothesis that hypoglycemia is associated with a poor outcome, even when controlling for initial severity. Methods: We looked for moderate (2.2 to 3.3 mmol/L) and severe (
RESEARCH
Open Access
Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients Pierre Kalfon1*, Yannick Le Manach2, Carole Ichai3, Nicolas Bréchot4, Raphaël Cinotti5, Pierre-François Dequin6, Béatrice Riu-Poulenc7, Philippe Montravers8, Djilalli Annane9, Hervé Dupont10, Michel Sorine11, Bruno Riou12,13 and on behalf of the CGAO-REA Study Group
Abstract Introduction: In a randomized controlled trial comparing tight glucose control with a computerized decision support system and conventional protocols (post hoc analysis), we tested the hypothesis that hypoglycemia is associated with a poor outcome, even when controlling for initial severity. Methods: We looked for moderate (2.2 to 3.3 mmol/L) and severe (
