産 業 医学

原

Jpn

J Ind

著

Health,

199;

34:

349-354

赤 血 球 遊 離 プ ロ トポ ル フ ィ リ ン(FEP)値 II.鉛 大

投与 ラ ッ トにお け るFEP値

森

昭

子*,原

田

幸

の性差 の性 差

一*,三

浦

SEX DIFFERENCE IN FREE ERYTHROCYTE

創*

PROTOPORPHYRIN

(FEP) LEVEL II. Sex Difference in FEP Level in Rats Exposed to Lead Shoko OHMORI,*Koichi HARADA*and Hajime MIURA* An in

experimental

FEP

study

level.

Each

group

(5%

glucose

group

(Pb

5mg/kg•EBW).

urinary

once

Donryu

33

male

solution

rats and

only),

low

Lead

coproporphyrin

determined

on

of

was

was

primarily

33

female

rats

lead

dose

group

injected

two

weeks

for

(Pb

acid

6wk,

out

divided

and

elucidate

and

blood

lead

sex

3 groups;

a

week

for

at

is,

control

high

lead

6wk.

FEP,

porphobilinogen (Pb-B)

difference

that

and

once

(ALA-U)

whole

to into

0.5mg/kg•EBW)

intraperitoneally

(CP-U), ƒÂ-aminolevulinic

every

carried was

dose Ht,

(PBG-U)

the

end

of

were

the

experi

the

experi

ment. Mean

value

ment

in

were

higher FEP

all in

In

in

Key

in

lead of

only

for to

only this

a

the

for

the

study

using

should

be

words;

dose

rats,

males

and

throughout

the

erythrocyte

Pb

period

level

of

of high

dose

group

sex this

lead

exposure

initial

(p