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Tomography. Author manuscript; available in PMC 2016 January 26. Published in final edited form as: Tomography. 2015 December ; 1(2): 136–144. doi:10.18383/j.tom.2015.00166.

Simultaneous T1 and T2 Brain Relaxometry in Asymptomatic Volunteers using Magnetic Resonance Fingerprinting Chaitra Badve1, Alice Yu2, Matthew Rogers2, Dan Ma3, Yiying Liu4, Mark Schluchter4, Jeffrey Sunshine1, Mark Griswold1,3, and Vikas Gulani1,3 1Department

of Radiology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA

Author Manuscript

2School

of Medicine, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA 3Department

of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA

4Biostatistics

and Bioinformatics Core, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA

Abstract

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Magnetic resonance fingerprinting (MRF) is a method of image acquisition that produces multiple MR parametric maps from a single scan. Here, we describe the normal range and progression of MRF-derived relaxometry values with age in healthy individuals. 56 normal volunteers (ages 11-71 years, M:F 24:32) were scanned. Regions of interest were drawn on T1 and T2 maps in 38 areas, including lobar and deep white matter, deep gray nuclei, thalami and posterior fossa structures. Relaxometry differences were assessed using a forward stepwise selection of a baseline model including either gender, age, or both, where variables were included if they contributed significantly (p