RESEARCH ARTICLE
Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells Nagendra Yaluri1☯, Shalem Modi1☯, Maykel López Rodríguez1, Alena Stančáková1, Johanna Kuusisto1,2, Tarja Kokkola1, Markku Laakso1,2* 1 Institute of Clinical Medicine, Internal Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland, 2 Department of Medicine, Kuopio University Hospital, Kuopio, Finland ☯ These authors contributed equally to this work. * [email protected]
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OPEN ACCESS Citation: Yaluri N, Modi S, López Rodríguez M, Stančáková A, Kuusisto J, Kokkola T, et al. (2015) Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells. PLoS ONE 10(11): e0142902. doi:10.1371/journal.pone.0142902 Editor: Nigel Irwin, University of Ulster, UNITED KINGDOM Received: February 17, 2015 Accepted: October 28, 2015 Published: November 11, 2015 Copyright: © 2015 Yaluri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stimulated insulin secretion in mouse pancreatic MIN6 βcells by 59% and 79% (p
Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells Nagendra Yaluri1☯, Shalem Modi1☯, Maykel López Rodríguez1, Alena Stančáková1, Johanna Kuusisto1,2, Tarja Kokkola1, Markku Laakso1,2* 1 Institute of Clinical Medicine, Internal Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland, 2 Department of Medicine, Kuopio University Hospital, Kuopio, Finland ☯ These authors contributed equally to this work. * [email protected]
a11111
OPEN ACCESS Citation: Yaluri N, Modi S, López Rodríguez M, Stančáková A, Kuusisto J, Kokkola T, et al. (2015) Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells. PLoS ONE 10(11): e0142902. doi:10.1371/journal.pone.0142902 Editor: Nigel Irwin, University of Ulster, UNITED KINGDOM Received: February 17, 2015 Accepted: October 28, 2015 Published: November 11, 2015 Copyright: © 2015 Yaluri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stimulated insulin secretion in mouse pancreatic MIN6 βcells by 59% and 79% (p
