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J Alzheimers Dis. Author manuscript; available in PMC 2017 June 18. Published in final edited form as: J Alzheimers Dis. 2016 June 18; 53(3): 955–965. doi:10.3233/JAD-151125.

Life’s Simple 7’s Cardiovascular Health Metrics are Associated with Hispanic/Latino Neurocognitive Function: HCHS/SOL Results

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Hector M. Gonzáleza,*, Wassim Tarrafb, Natalia Gouskovac, Carlos J. Rodríguezd, Tatjana Rundeke, Ellen Groberf, Amber Pirzadag, Patricia Gonzálezh, Pamela L. Lutseyi, Alvaro Camachoj, Martha L. Daviglusg, Clinton Wrighte, and Thomas H. Mosleyk aDepartment

of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA

bInstitute

of Gerontology and the Department of Health Care Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA cUNC

Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA

dPublic

Heath Sciences, Wake Forest University, Winston-Salem, NC, USA

eDepartment fThe

of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA

Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY,

USA

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gInstitute

for Minority Health Research, College of Medicine at Chicago, University of Illinois at Chicago, Chicago, IL, USA hInstitute

for Behavioral and Community Health, Graduate School of Public Health, San Diego State University, San Diego, CA, USA

iDivision

of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA

jDepartments

of Psychiatry, Family Medicine, and Public Health, University of California at San Diego, San Diego, CA, University of California, San Diego School of Medicine, La Jolla, CA, USA

kDepartment

of Medicine (Geriatrics) and Neurology, University of Mississippi Medical Center, Jackson, MS, USA

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Abstract

*

Correspondence to: Hector M. González, PhD, Epidemiology and Biostatistics, Michigan State University, 909 Fee Road, East Lansing, MI 48824, USA. Tel.: +1 517 884 6628; Fax: +1 517 432 1130; [email protected]. Handling Associate Editor: David Libon Authors’ disclosures available online (http://jalz.com/manuscript-disclosures/15-1125r2). SUPPLEMENTARY MATERIAL The supplementary material is available in the electronic version of this article: http://dx.doi.org/10.3233/JAD-151125.

González et al.

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Background—Hispanics/Latinos are purportedly at increased risk for neurocognitive decline and dementias. Without dementia cures, low-cost, well-tolerated public health means for mitigating neurocognitive decline are needed. Objective—We examined associations between neurocognition and cardiovascular health (CVH) metrics (Life’s Simple 7; LS7) among diverse Hispanics/Latinos. We hypothesized that higher LS7 would be associated with healthier brain function (neurocognitive performance). Methods—We used baseline (2008–2011) Hispanic Community Health Study/Study of Latinos (HCHS/SOL; N = 9,623; ages 45–74 years) to examine neurocognition in relation to CVH LS7 scores.

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Results—In age and sex adjusted models, a one unit LS7 score increase (range = 0–14) was associated with higher neurocognitive function on the B-SEVLT sum (0.23 [p