Some Properties Shared by Amino Acids and Entero-oxyntin ELPIDIO C. MARIANO, M.D., ANDREW BELONI, B.S.E., JOHN H. LANDOR, M.D.
From the Department of Surgery, CMDNJ-Rutgers Medical School, Piscataway, New Jersey
the intestinal phase of gastric secretion has been thought
oht due to the release of a hormone from the gut mucosa, and several properties have been attributed to this "-ct unidentified hormone. An amino acid solution, known lostimnulate gastric secretion, was tested to see if it possesses voeral of these properties, i.e., inactivation by the liver, and te ability to augment the maximum responses to pentaastrin and histamine. In six dogs with Heidenhain pouches he gastric secretory responses to peripheral and portal niravenous administration of a solution of mixed L-amino cids were measured. The mean peak response of three such wparate peripheral infusions in each dog was 370 txEq/30 inutes while the peak response to intraportal infusion was hn 45 ,uEq/30 minutes (p
From the Department of Surgery, CMDNJ-Rutgers Medical School, Piscataway, New Jersey
the intestinal phase of gastric secretion has been thought
oht due to the release of a hormone from the gut mucosa, and several properties have been attributed to this "-ct unidentified hormone. An amino acid solution, known lostimnulate gastric secretion, was tested to see if it possesses voeral of these properties, i.e., inactivation by the liver, and te ability to augment the maximum responses to pentaastrin and histamine. In six dogs with Heidenhain pouches he gastric secretory responses to peripheral and portal niravenous administration of a solution of mixed L-amino cids were measured. The mean peak response of three such wparate peripheral infusions in each dog was 370 txEq/30 inutes while the peak response to intraportal infusion was hn 45 ,uEq/30 minutes (p
