RESEARCH ARTICLE
Sperm DNA fragmentation index does not correlate with blastocyst aneuploidy or morphological grading Itai Gat1,2,3, Katelynn Tang1, Kevin Quach1, Valeriy Kuznyetsov1, Ran Antes1, Melissa Filice1, Khaled Zohni1, Clifford Librach1,4,5,6* 1 CReATe Fertility Centre, Toronto, Canada, 2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 3 Pinchas Borenstein Talpiot Medical Leadership Program, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel, 4 Department of Obstetrics & Gynecology, University of Toronto, Toronto, Canada, 5 Department of Physiology, University of Toronto, Toronto, Canada, 6 Department of Gynecology, Women’s College Hospital, Toronto, Canada
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OPEN ACCESS Citation: Gat I, Tang K, Quach K, Kuznyetsov V, Antes R, Filice M, et al. (2017) Sperm DNA fragmentation index does not correlate with blastocyst aneuploidy or morphological grading. PLoS ONE 12(6): e0179002. https://doi.org/ 10.1371/journal.pone.0179002 Editor: Wendy Dean, The Babraham Institute, UNITED KINGDOM Received: February 26, 2017 Accepted: May 22, 2017 Published: June 7, 2017 Copyright: © 2017 Gat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors received no specific funding for this work. Competing interests: The authors have declared that no competing interests exist.
* [email protected]
Abstract High DNA fragmentation index (DFI) may be associated with poor outcome after IVF. Our aim was to determine whether DFI impacts blastocyst quality or clinical outcome. This retrospective study included 134 couples who underwent 177 IVF-ICSI and pre-implantation genetic screening (PGS) cycles during January 1st, 2014—March 31st, 2016 and had documented previous DFI. Group 1 (DFI>30%) encompassed 25 couples who underwent 36 cycles; Group 2 (DFI 15–30%) included 45 couples and 57 cycles; group 3 (DFI
Sperm DNA fragmentation index does not correlate with blastocyst aneuploidy or morphological grading Itai Gat1,2,3, Katelynn Tang1, Kevin Quach1, Valeriy Kuznyetsov1, Ran Antes1, Melissa Filice1, Khaled Zohni1, Clifford Librach1,4,5,6* 1 CReATe Fertility Centre, Toronto, Canada, 2 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 3 Pinchas Borenstein Talpiot Medical Leadership Program, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel, 4 Department of Obstetrics & Gynecology, University of Toronto, Toronto, Canada, 5 Department of Physiology, University of Toronto, Toronto, Canada, 6 Department of Gynecology, Women’s College Hospital, Toronto, Canada
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OPEN ACCESS Citation: Gat I, Tang K, Quach K, Kuznyetsov V, Antes R, Filice M, et al. (2017) Sperm DNA fragmentation index does not correlate with blastocyst aneuploidy or morphological grading. PLoS ONE 12(6): e0179002. https://doi.org/ 10.1371/journal.pone.0179002 Editor: Wendy Dean, The Babraham Institute, UNITED KINGDOM Received: February 26, 2017 Accepted: May 22, 2017 Published: June 7, 2017 Copyright: © 2017 Gat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors received no specific funding for this work. Competing interests: The authors have declared that no competing interests exist.
* [email protected]
Abstract High DNA fragmentation index (DFI) may be associated with poor outcome after IVF. Our aim was to determine whether DFI impacts blastocyst quality or clinical outcome. This retrospective study included 134 couples who underwent 177 IVF-ICSI and pre-implantation genetic screening (PGS) cycles during January 1st, 2014—March 31st, 2016 and had documented previous DFI. Group 1 (DFI>30%) encompassed 25 couples who underwent 36 cycles; Group 2 (DFI 15–30%) included 45 couples and 57 cycles; group 3 (DFI
