Squamous Cell Carcinoma in a Free-ranging Bighorn Sheep (Ovis canadensis californiana) Author(s): William J. Foreyt, Gordon A. Hullinger, and Charles W. Leathers, Source: Journal of Wildlife Diseases, 27(3):518-520. Published By: Wildlife Disease Association DOI: http://dx.doi.org/10.7589/0090-3558-27.3.518 URL: http://www.bioone.org/doi/full/10.7589/0090-3558-27.3.518

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Journal

Squamous (Ovis

Cell Carcinoma

canadensis

An

ABSTRACT:

A. Hullinger, and Charles

State

Washington

oral

University,

Pullman,

teeth

were

squamous

missing

was predominantly maxillary bones bilaterally

Key

cell

or

loose.

The

ets

Squamous

plasia,

tumor,

histopatho!ogy,

Ovis

canadensis

of the

neo-

californiana,

case

report.

later,

Washington

it died

the

right

the hock. greenish, into

the

99164,

At necropsy, weighed 37.3 was a fluctuant

The caseated

many

and

was

pockets.

many

to those

in the

swelling material The

were

nests

mucosa

of

to

right

dental

ulcerated

oral

palate,

through

the

to intact

nasal

cells

often

separated

tissue

nent

nucleoli.

seen,

but

with

Mitotic

figures

often

atypical.

varied from to hylanized,

arcade, and Next to these

were

identified

in some

were

adjacent

to ulcerated

the other teeth, the

teeth gingiva

were was

and ulcerated, and a 1 to 2 cm socket contained a small amount pacted ingesta. Adjacent tissue dened and covered with a thin granulation illae

were

tissue, markedly

and

the

the

maxillae

contained

and

diameter of imwas redlayer of

overlying

bilaterally

many

of

Neutrophils

been replaced

were

next to ulcerated

bones sur-

In

chalky 518

the

night

node,

normal

faced

by

cords

in rarely

Cytoplasm vacuolated and

ke-

bridges

areas.

Tumor

oral

cells

epithelium mineralized

75%

of the maxib-

obliterated by fibrous

located

oval,

promi-

were

poorly Oven

had or

to

intercellular

between bone.

!ary bones plastic cells

max-

cut

Prominent

were Nuclei

greatly

eosinophilic and brightly eosinophilic,

located

spicules

thickened

and softened. Most of the maxillary were replaced by soft tissue. On face,

loose. eroded

.

round multiple

arcade retained only 1 molar which was freely moveable. Only the first premolan was missing from the upper left dental

bands

cells

varied

contained

ne-

thick

inflammatory

multiple,

were

ratinized

centrally by

1). Tumor pleomorphic.

vesiculated,

often

epithelium.

were

mixed (Fig. and

epithe-

from

tumor

to

Inter-

of neoplastic

of

sometimes

and

intestine. normal.

and

were

attached

region,

all sections of the oral lecharacterized by mu!-

hard

bones

and

or serous. compati-

small

cords

the

debris polygonal

size

scant

pelvic

invaded

cellular large,

similar

were

grossly

and which

stippled

was filled with that extended upper

in the

ha! cells

and

foci

morphologicalby in the

Islands

sheep There over

was

mesentery

of fibrous

distal

fat

hydatigena

tissues

retropharynenlarged

miliary

Taenza

maxillary

USA).

right

pock-

mandibles

maxillae.

were

crotic

and

and

The

greatly

white

cysticerci

tiple

Animal (Pullman,

immediately

The

body

with

tracts

was

Histologically, sions were similar,

submitted

Washington Laboratory

the adult female kg and was emaciated. subcutaneous swelling

metatarsus

contained

nab

Microbiology

exudate.

node

cestodes

a rural road near Loomis, (USA; 48#{176}50’N, 117#{176}15’W).

the same day to Disease Diagnostic

occasional

normal.

to the

sheep,

of Veterinary

white

lymph

Two

it was

bighorn

and

Internally,

In January 1990, a free-ranging California bighorn sheep (Ovis canadensis californiana) was observed to be depressed

days

foci

geal

tumor

cell carcinoma,

Department

of thick

ble

words:

Three

Sheep

USA

appeared

symmetrical.

on

99164,

white

carcinoma

confined to the shape and was unusual because

and weak Washington

Bighorn

W. Leathers,

Washington

which invaded maxillary bones with metastasis to the right retropharyngeal lymph node was diagnosed in a free-ranging California bighorn sheep (Ovis canadensis californiana ) from Washington. Much of the maxillae had been replaced with tumor and reactive tissue, and many

27(3), 1991, pp. 518-520 Disease Association 1991

Diseases, © Wildlife

californiana)

William J. Foreyt, Gordon Pathology,

in a Free-ranging

of Wildlife

by

neotissue.

predominantly

oral mucosa. retropharyngeal

nodal and

architecture islands

of

lymph was malignant

ef-

SHORT

epithelial cells morpho!ogically similar those described previously. Occasional gregates of lymphoid tissue remained the margins of the node. The capsule thickened and many capsular vessels tamed tumor emboli. Hepatic cords contained prominent cumubations phous

of

material

pale

amphophilic

that

stained

amyloid with Congo were in all portions

to agat was conac-

amor-

positively

for

ned. These deposits of hepatic lobules, es-

pecially penipontally. Renal glomerubi and intenstitium also contained accumulations of amyloid. Cardiac and skeletal muscle contained occasional basophilic multinucleate cysts of Sarcocystis approximately 40 sociated inflammation. mandible were The destructive lary bones was a squamous

cell

x

sp. 80

histologically mass histologically carcinoma

tm, Lung,

which

were

without thyroid

asand

normal. involving maxilconfirmed as with

metastasis

to a regional

lymph

paraffin-embedded deposited in the

node.

A representative of the tumor of Comparative

(Armed Washington, Number had been

cells

and

reactive

was

unusual as well

D.C. 2267195). replaced fibrous

um

is the

likely

mor

because cranial

loss

bone of the

ulcerations

aspects

of the

upper dental arcades. well differentiated and inately illary

tissue.

of teeth.

source

deep

Institute 20306, Much with

was

of PaUSA; of the tumor

This

bilaterally

as eroding

and

at the

Forces

in being

loosening

519

block Registry

Pathology thobogy, Accession maxil!ae

rica!,

COMMUNICATiONS

tumor

symmetand Oral

causing epitheli-

primary were right

tupresent

and

left

The neoplasm was remained predom-

confined to the shape bone, without extension

of the through

maxnasa!

epithe!ium. Hepatic and renal amyboidosis was considered secondary to chronic inflammation associated tumor. Emaciation

with the destructive of the sheep likely

ne-

520

JOURNAL

sulted the

OF WiLDLIFE

from

an

inability

extensive oral Few neopbasms

bighorn sheep. the pituitary

forage

due

to

in

neoplasms of wild

been

reported

a bighonn

x

but (Williams,

in

et a!., 1983; Sundberg and 1984), but to our knowledge,

We

thank

King, life,

first

squamous

cell

in a free-ranging Gordon

Washington for

LaVoy

in this

sheep.

and

Jerry

of

W.

tary

53:

HUBBARD,

C.

ER.

1983.

Zoo

Animal

Wild-

case.

G.

asites

E.,

L.

1981.

NETTLES.

of

C.

white-tailed

R. Hayes,

V. A. Nettles,

Miscellaneous

Publication

bers

Station,

62-71.

Research

.

1980.

In

animals,

R.

The J.

Smithsonian

deer,

W. and

R.

F. E.

Number Tallahassee,

V.

AND

In Diseases

and

F. par-

Davidson, Kellog

7, Tall Florida,

F. (eds.). Tim-

K. C. FLETCH-

animals.

An overview Montali

of tumors

pathology

and

C.

Press,

P.,

AND

S.

E.

cell carcinoma Journal E.

wildlife

of the 5.

1982.

of

in zoo of zoo

Migaki

(eds.).

Washington,

D.C.,

Wyoming

W.

R. Jolley,

Fish

and

Wyoming,

pp.

American

cervix

publication

in a black-

Veterinary

Med-

1445-1446.

In

Diseases

of

E. T.

Thorne,

N.

2nd

ed.,

and

R. C. Bergstrom

Game

Department,

261-269.

pp.

for

1984.

MCDONALD.

of the

Neoplasias.

in Wyoming,

Kingston,

Received

Journal

33-40.

comparative

Institution

J.

WILLIAMS,

enne,

Orga-

531-547.

buck.

SATTERFIELD,

Neoplasia.

alimen-

Health

AND

14:

ical Association 185: COSCROVE,

upper

World

in zoo

Medicine

J.

SUNDBERG,

CITED

of the the

Neoplasia

Squamous

LITERATURE

Indochina Veterinary

932.

B., R. E. SCHMIDT,

R.

P. ANDERSON.

145-166.

animals.

pp.

of

Jour185-194.

in an

American

177:

Bulletin

59:

M.

AND

the

captive

at necropsy.

Tumours

1976.

tract.

MONTALI,

carcinoma

bighorn

Department

assistance

1982;

of

1977. in

Institute

carcinoma

Association

K.

nization

et

is the

Journal

1950-1960.

found

reptiles

D. L. JANSSEN,

deer.

Vet-

K. BENIRSCHKE.

Cancer

cell

A

Royal

during

neoplasia and

Squamous

Medical

Hubbard McDonald,

birds, National

P. K.,

sika HEAD,

of

animals:

the

816-822.

AND

rate

animal, of the

1980.

et a!., 1980;

Williams,

and

ENSLEY,

72:

L. GRINER,

Nature

farm at

London,

Record

M.,

EFFRON,

of

examined

College,

wild

reported ungulates

Tumours

tumours

Veterinary

nal

Cosgrove

reported

1981;

of an

1960.

of

eninary

mouflon

(Cotchin, 1960; Head, 1976; Effron 1977; Ensley et a!., 1980; Montali,

this

E.

COTCHIN,

in

details of these 1982). Ma-

have been and domestic

al.,

1991

survey

These include adenomas and adrenal glands, and

(Ovis musimon), not reported

lignant a variety

VOL. 27, NO. 3, JULY

to

lesions. have

adenocarcinoma sheep were

DISEASES,

30 July

1990.

(eds.). Chey-