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Neuroimage. Author manuscript; available in PMC 2017 July 01. Published in final edited form as: Neuroimage. 2016 July 1; 134: 328–337. doi:10.1016/j.neuroimage.2016.03.070.

Structural Connectivity Relates to Perinatal Factors and Functional Impairment at 7 Years in Children Born Very Preterm

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Deanne K. Thompson, PhDa,b,c, Jian Chen, MEa,d, Richard Beare, PhDa,d, Christopher L. Adamson, PhDa, Rachel Ellis, PhDa, Zohra M. Ahmadzai, BBiomed (hons)a, Claire E. Kelly, BSc (hons)a, Katherine J. Lee, PhDa,c, Andrew Zalesky, PhDe,f, Joseph Y.M. Yang, MBChBa,g, Rodney W. Hunt, PhDa,c,h, Jeanie L.Y. Cheong, MDa,i,j, Terrie E. Inder, MBChB, MDk, Lex W. Doyle, MDa,c,i,j, Marc L. Seal, PhDa,c, and Peter J. Anderson, PhDa,c aMurdoch

Childrens Research Institute, 50 Flemington Road, Parkville, Victoria, 3052, Australia

bFlorey

Institute of Neuroscience and Mental Health, 30 Royal Parade, Parkville, Victoria, 3052, Australia cDepartment

of Paediatrics, University of Melbourne, 50 Flemington Road, Parkville, Victoria, 3052, Australia dDepartment

of Medicine, Monash Medical Centre, Monash University, 246 Clayton Rd, Melbourne, Victoria, 3168, Australia

eDepartment

of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, 161 Barry St, Carlton, Victoria, 3053, Australia

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fMelbourne

School of Engineering, Building 173, University of Melbourne, Parkville, Victoria, 3010, Australia gDepartment

of Neurosurgery, Royal Children’s Hospital, 50 Flemington Road, Parkville, Victoria, 3052, Australia

hDepartment

of Neonatal Medicine, The Royal Children’s Hospital, 50 Flemington Road, Parkville, Victoria, 3052, Australia

iWomen’s

Newborn Research Centre, Royal Women’s Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia jDepartment

of Obstetrics and Gynaecology, University of Melbourne, 20 Flemington Rd, Parkville, Victoria, 3052, Australia

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kBrigham

and Women’s Hospital, 75 Francis St, Boston, Massachusetts, 02115, United States

Abstract

Corresponding author: Deanne K. Thompson, Victorian Infant Brain Studies (VIBeS), Murdoch Childrens Research Institute, 50 Flemington Road, Parkville, Victoria, 3052, Australia, Phone +61 3 99366708, Fax +61 3 93481391, [email protected]. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Thompson et al.

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Objective—To use structural connectivity to (1) compare brain networks between typically and atypically developing (very preterm) children, (2) explore associations between potential perinatal developmental disturbances and brain networks, and (3) describe associations between brain networks and functional impairments in very preterm children. Methods—26 full-term and 107 very preterm 7-year-old children (born