EXPERIMENTAL AND THERAPEUTIC MEDICINE 9: 1331-1335, 2015
Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique TIAN TANG and DUAN‑LIAN ZHANG Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China Received September 13, 2014; Accepted January 30, 2015 DOI: 10.3892/etm.2015.2287 Abstract. The aim of the present study was to investigate the association of extracellular matrix metalloproteinase inducer (EMMPRIN) and human epidermal growth factor receptor (HER)‑2 protein expression in papillary thyroid carcinoma with lymph node metastasis (LNM), as well as the correlation between the two types of protein expression. A quantum dot‑based immunofluorescence technique was used to detect EMMPRIN and HER‑2 protein expression in 75 papillary thyroid carcinoma cases (including 70 cases of papillary thyroid carcinoma tissues and 5 cases of peri‑tumor tissues). The positive rate and expression of EMMPRIN and HER‑2 were compared and observed. The positive rate of EMMPRIN was 75.71% in papillary thyroid carcinoma tissues and 20.00% in peri‑tumor tissues (P0.05). The expression of EMMPRIN and HER‑2 in papillary thyroid carcinoma was significantly associated with LNM (P
Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor‑2 protein expression in papillary thyroid carcinoma using a quantum dot‑based immunofluorescence technique TIAN TANG and DUAN‑LIAN ZHANG Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China Received September 13, 2014; Accepted January 30, 2015 DOI: 10.3892/etm.2015.2287 Abstract. The aim of the present study was to investigate the association of extracellular matrix metalloproteinase inducer (EMMPRIN) and human epidermal growth factor receptor (HER)‑2 protein expression in papillary thyroid carcinoma with lymph node metastasis (LNM), as well as the correlation between the two types of protein expression. A quantum dot‑based immunofluorescence technique was used to detect EMMPRIN and HER‑2 protein expression in 75 papillary thyroid carcinoma cases (including 70 cases of papillary thyroid carcinoma tissues and 5 cases of peri‑tumor tissues). The positive rate and expression of EMMPRIN and HER‑2 were compared and observed. The positive rate of EMMPRIN was 75.71% in papillary thyroid carcinoma tissues and 20.00% in peri‑tumor tissues (P0.05). The expression of EMMPRIN and HER‑2 in papillary thyroid carcinoma was significantly associated with LNM (P
