CLINICAL
AND
LABORATORY OBSERVATIONS
Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia Hisham Abdel-Azim, MD,* Baro Jovi-Usude, BSc,* Chelsea Balian, PNP,* Ami J. Shah, MD,w Shinyi Tang, PNP,z Arpan Sinha, MD,z Neena Kapoor, MD,* and Kris M. Mahadeo, MD, MPHz
Summary: Cases of pregnancy-associated severe aplastic anemia (SAA) have been reported in the literature with historically high rates of mortality. We report the case of a 17-year-old female diagnosed with SAA at 26 weeks of gestation. She experienced intrauterine fetal demise and did not achieve hematologic remission after delivery. She received a histocompatible sibling donor bone marrow transplant 7 weeks after her diagnosis and remains in remission, at 1-year posttransplant. We review available literature and suggest that when a histocompatible sibling donor is available, bone marrow transplantation should be considered as a first-line therapy for patients with pregnancy-associated SAA. Key Words: BMT, aplastic anemia, pregnancy
(J Pediatr Hematol Oncol 2015;37:319–321)
C
lassically, severe aplastic anemia (SAA) has been diagnosed based upon the following criteria: (1) marrow of
AND
LABORATORY OBSERVATIONS
Successful Bone Marrow Transplantation of an Adolescent Young Adult Female With Pregnancy-associated Aplastic Anemia Hisham Abdel-Azim, MD,* Baro Jovi-Usude, BSc,* Chelsea Balian, PNP,* Ami J. Shah, MD,w Shinyi Tang, PNP,z Arpan Sinha, MD,z Neena Kapoor, MD,* and Kris M. Mahadeo, MD, MPHz
Summary: Cases of pregnancy-associated severe aplastic anemia (SAA) have been reported in the literature with historically high rates of mortality. We report the case of a 17-year-old female diagnosed with SAA at 26 weeks of gestation. She experienced intrauterine fetal demise and did not achieve hematologic remission after delivery. She received a histocompatible sibling donor bone marrow transplant 7 weeks after her diagnosis and remains in remission, at 1-year posttransplant. We review available literature and suggest that when a histocompatible sibling donor is available, bone marrow transplantation should be considered as a first-line therapy for patients with pregnancy-associated SAA. Key Words: BMT, aplastic anemia, pregnancy
(J Pediatr Hematol Oncol 2015;37:319–321)
C
lassically, severe aplastic anemia (SAA) has been diagnosed based upon the following criteria: (1) marrow of
