Accepted Manuscript Title: Surgery for Reflux Induced Airway Disease: A Systematic Review Author: Ryan L. Sload Matthew T. Brigger PII: DOI: Reference:
S0165-5876(14)00261-4 http://dx.doi.org/doi:10.1016/j.ijporl.2014.04.049 PEDOT 7117
To appear in:
International Journal of Pediatric Otorhinolaryngology
Received date: Revised date: Accepted date:
8-1-2014 24-4-2014 26-4-2014
Please cite this article as: Ryan L.Sload, Matthew T.Brigger, Surgery for Reflux Induced Airway Disease: A Systematic Review, International Journal of Pediatric Otorhinolaryngology http://dx.doi.org/10.1016/j.ijporl.2014.04.049 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Surgery for Reflux Induced Airway Disease: A Systematic Review
ip t
Ryan L. Sload MD LT MC USN Naval Medical Center San Diego Department of Otolaryngology – Head and Neck Surgery
us
cr
Matthew T. Brigger, MD, MPH CDR MC USN Naval Medical Center San Diego Department of Otolaryngology – Head and Neck Surgery Assistant Professor of Surgery Uniformed Services University of the Health Sciences
Matthew T. Brigger, MD, MPH 619 532 5617 [email protected] Naval Medical Center San Diego Department of Otolaryngology – Head and Neck Surgery 34520 Bob Wilson Drive Suite 200 San Diego, CA 92134 This work was presented as a poster at the 2013 Annual Meeting of the American Academy of Otolaryngology – Head and Neck Surgery. The views expressed in this manuscript are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defense, nor the U.S. Government. Conflict of Interest Statement: The authors have no conflicts of interest to disclose.
Ac ce pt e
d
M
an
Corresponding author: Phone: Email: Address:
Abstract
Objectives:
1. Evaluate the current evidence regarding the efficacy and safety of anti-reflux surgery for the treatment of severe gastroesophageal reflux related airway disease in children. 2. Provide evidence based recommendations regarding indications and outcomes of anti-reflux surgery for airway disease in children.
Page 1 of 16
Methods: An a priori protocol was defined to identify all articles addressing anti-reflux surgery for the treatment of reflux related airway disease in children where details regarding the diagnosis, treatment and outcomes were clearly presented. The search was inclusive of all
ip t
references available through August 30, 2013 and included electronic databases to identify candidate articles as well as a comprehensive series of crosschecks. The two authors
cr
independently determined which references met inclusion criteria, extracted data, and assigned
us
levels of evidence. Data were pooled using a random effects model due to significant study heterogeneity.
an
Results: Fourteen articles met inclusion criteria. The overall level of evidence was grade C. There was significant heterogeneity among the studies (I2 = 82.7%;p
S0165-5876(14)00261-4 http://dx.doi.org/doi:10.1016/j.ijporl.2014.04.049 PEDOT 7117
To appear in:
International Journal of Pediatric Otorhinolaryngology
Received date: Revised date: Accepted date:
8-1-2014 24-4-2014 26-4-2014
Please cite this article as: Ryan L.Sload, Matthew T.Brigger, Surgery for Reflux Induced Airway Disease: A Systematic Review, International Journal of Pediatric Otorhinolaryngology http://dx.doi.org/10.1016/j.ijporl.2014.04.049 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Surgery for Reflux Induced Airway Disease: A Systematic Review
ip t
Ryan L. Sload MD LT MC USN Naval Medical Center San Diego Department of Otolaryngology – Head and Neck Surgery
us
cr
Matthew T. Brigger, MD, MPH CDR MC USN Naval Medical Center San Diego Department of Otolaryngology – Head and Neck Surgery Assistant Professor of Surgery Uniformed Services University of the Health Sciences
Matthew T. Brigger, MD, MPH 619 532 5617 [email protected] Naval Medical Center San Diego Department of Otolaryngology – Head and Neck Surgery 34520 Bob Wilson Drive Suite 200 San Diego, CA 92134 This work was presented as a poster at the 2013 Annual Meeting of the American Academy of Otolaryngology – Head and Neck Surgery. The views expressed in this manuscript are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defense, nor the U.S. Government. Conflict of Interest Statement: The authors have no conflicts of interest to disclose.
Ac ce pt e
d
M
an
Corresponding author: Phone: Email: Address:
Abstract
Objectives:
1. Evaluate the current evidence regarding the efficacy and safety of anti-reflux surgery for the treatment of severe gastroesophageal reflux related airway disease in children. 2. Provide evidence based recommendations regarding indications and outcomes of anti-reflux surgery for airway disease in children.
Page 1 of 16
Methods: An a priori protocol was defined to identify all articles addressing anti-reflux surgery for the treatment of reflux related airway disease in children where details regarding the diagnosis, treatment and outcomes were clearly presented. The search was inclusive of all
ip t
references available through August 30, 2013 and included electronic databases to identify candidate articles as well as a comprehensive series of crosschecks. The two authors
cr
independently determined which references met inclusion criteria, extracted data, and assigned
us
levels of evidence. Data were pooled using a random effects model due to significant study heterogeneity.
an
Results: Fourteen articles met inclusion criteria. The overall level of evidence was grade C. There was significant heterogeneity among the studies (I2 = 82.7%;p
