lirilish jotirmd of Dernuitologif 11^92) 126. 172-178.

Systemic glucocorticoid treatment decreases serum concentrations of carboxyterminal propeptide of type I procollagen and aminoterminal propeptide of type III procollagen A.OiKARINEN. P.AUTIO." J.VlJORl.t AND

K.VAANANEN.$

LEILA RISTELI.1 U.KIISTALA^

[)epartmeni!i of Dermnloknifi. t Analonifi. "i Mexikai Biochemistry and § Clinical Ciiemislry. Vntversity of Oulii. I'inhmd t Deaconess Jnslituic of Oulii. Oulu. I'inland * Department of Denmtoloijti. Cenlral Mililarn Hospilal. Heininki. l-inlatid Accepted for publication 2 Septemhcr

Summary

The effect of systemic glucocorticoid treatment on collagen synthesis in patients with various dermatoses was studied by measuring the carboxyterminal propeptide of type I procollagen (PTCP) and theaminotenniiuil propeptide of type III procollagen (PlIINP) in serum. Changes in the propeptide concentrations were compared with those of osteocalcin. which reflects osteoblastic activity, and tartrate resistant acid phosphatase (TRAP), which reflects osteoclastic activity. The treatment caused significant decreases in levels of PICP. PIIINP and osteocalcin of 38. 34 and 49%. respectively (P

Systemic glucocorticoid treatment decreases serum concentrations of carboxyterminal propeptide of type I procollagen and aminoterminal propeptide of type III procollagen.

The effect of systemic glucocorticoid treatment on collagen synthesis in patients with various dermatoses was studied by measuring the carboxyterminal...
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