MOLECULAR AND CLINICAL ONCOLOGY 1: 507-510, 2013
Long‑term results of concurrent chemoradiotherapy for T3/T4 locally advanced nasopharyngeal carcinoma CAN XIAO1*, LILI WANG2*, YANG JIAO3, KEKANG SUN3, SONGBING QIN2, XIAOTING XU2, JIAN GUO2 and JUYING ZHOU2 Departments of 1Stomatology and 2Radiation Oncology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215006; 3School of Radiation Medicine and Protection, Medical College of Soochow University, Soochow University, Suzhou, Jiangsu 215123, P.R. China Received November 5, 2012; Accepted January 24, 2013 DOI: 110.3892/mco.2013.75 Abstract. Nasopharyngeal carcinoma (NPC) is one of the most commonly diagnosed head and neck malignancies. This study investigated the outcome of locally advanced NPC patients on concurrent intensity‑modulated radiation therapy (IMRT) and chemotherapy with docetaxel, cisplatin and 5‑fluorouracil (TPF). A total of 226 patients with locally advanced NPC received IMRT, with a total dose of 65‑70 Gy and concurrent chemotherapy, with 2 cycles of TPF administered during radiotherapy, between March, 2005 and March, 2007. An additional 2 to 4 cycles of chemotherapy were administered every 21 days following radiotherapy. With a median follow‑up time of 35 months (range, 7‑60), the 5‑year overall survival (OS) rate was 81.4%, with 93.6 and 75.0% for T3 and T4 lesions, respectively, (P=0.001). The 5‑year progression‑free survival (PFS) was 50.4%, with 66.7 and 46.9% for T3 and T4 lesions, respectively (P
Long‑term results of concurrent chemoradiotherapy for T3/T4 locally advanced nasopharyngeal carcinoma CAN XIAO1*, LILI WANG2*, YANG JIAO3, KEKANG SUN3, SONGBING QIN2, XIAOTING XU2, JIAN GUO2 and JUYING ZHOU2 Departments of 1Stomatology and 2Radiation Oncology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215006; 3School of Radiation Medicine and Protection, Medical College of Soochow University, Soochow University, Suzhou, Jiangsu 215123, P.R. China Received November 5, 2012; Accepted January 24, 2013 DOI: 110.3892/mco.2013.75 Abstract. Nasopharyngeal carcinoma (NPC) is one of the most commonly diagnosed head and neck malignancies. This study investigated the outcome of locally advanced NPC patients on concurrent intensity‑modulated radiation therapy (IMRT) and chemotherapy with docetaxel, cisplatin and 5‑fluorouracil (TPF). A total of 226 patients with locally advanced NPC received IMRT, with a total dose of 65‑70 Gy and concurrent chemotherapy, with 2 cycles of TPF administered during radiotherapy, between March, 2005 and March, 2007. An additional 2 to 4 cycles of chemotherapy were administered every 21 days following radiotherapy. With a median follow‑up time of 35 months (range, 7‑60), the 5‑year overall survival (OS) rate was 81.4%, with 93.6 and 75.0% for T3 and T4 lesions, respectively, (P=0.001). The 5‑year progression‑free survival (PFS) was 50.4%, with 66.7 and 46.9% for T3 and T4 lesions, respectively (P
