Tertiary Structural Constraints on Protein Evolutionary Diversity: Templates, Key Residues and Structure Prediction John Overington, Mark S. Johnson, Andrej Sali and Tom L. Blundell Proc. R. Soc. Lond. B 1990 241, 132-145 doi: 10.1098/rspb.1990.0077
Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction.
The pattern of residue substitution in divergently evolving families of globular proteins is highly variable. At each position in a fold there are con...