Br. J. Pharmacol. (1990), 99, 317-322
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Macmiflan Press Ltd, 1990
The action of atriopeptin III on renal function in two models of chronic renal failure in the rat 'Edward J. Johns & 2Boleslaw Rutkowski Department of Physiology, The Medical School, Birmingham B15 2TJ 1 The natriuretic and diuretic effects of atriopeptin III (125, 250 and 500 ng kg 1, i.v.) were studied in of rats anaesthetized with pentobarbitone which were either sham controls, unilaterally nephrectomized controls, adenine-fed or subtotal nephrectomy chronic renal failure models. 2 Atriopeptin III given at these doses to the sham control animals had no effect on blood pressure, renal blood flow or glomerular filtration rate but reversibly increased urine flow, between 46% to 54%, absolute sodium excretion, between 52% to 61%, and fractional sodium excretion, between 48% to 54% (all P values
Z:&/
Macmiflan Press Ltd, 1990
The action of atriopeptin III on renal function in two models of chronic renal failure in the rat 'Edward J. Johns & 2Boleslaw Rutkowski Department of Physiology, The Medical School, Birmingham B15 2TJ 1 The natriuretic and diuretic effects of atriopeptin III (125, 250 and 500 ng kg 1, i.v.) were studied in of rats anaesthetized with pentobarbitone which were either sham controls, unilaterally nephrectomized controls, adenine-fed or subtotal nephrectomy chronic renal failure models. 2 Atriopeptin III given at these doses to the sham control animals had no effect on blood pressure, renal blood flow or glomerular filtration rate but reversibly increased urine flow, between 46% to 54%, absolute sodium excretion, between 52% to 61%, and fractional sodium excretion, between 48% to 54% (all P values
