Accepted Article

Received Date : 02-Oct-2013 Revised Date : 26-Aug-2014 Accepted Date : 29-Sep-2014 Article type : Regular Paper

The activity of satellite cells and myonuclei following 8 weeks of strength training in young men with suppressed testosterone levels

1,2

6

Thue Kvorning, 3Fawzi Kadi, 4Peter Schjerling, 5Marianne Andersen, 5Kim Brixen,

Charlotte Suetta and 7Klavs Madsen

1

Team Danmark, Idraettens Hus, Broendby, Denmark.

2

Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Denmark.

3

School of Health and Medical Sciences, Örebro University, Örebro, Sweden.

4

Institute of Sports Medicine, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy

Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. 5

Department of Endocrinology, Odense University Hospital, Denmark.

6

Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital.

7

Department of Food and Nutrition, and Sport Exercise, University of Gothenburg.

Corresponding author: Thue Kvorning, Telephone: +45 51922319 Email: [email protected] Address: Team Danmark, Idraettens Hus, Broendby Stadion 20, DK-2605 Broendby, Denmark.

Running title: training, testosterone, satellite cells and myonuclei

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an 'Accepted Article', doi: 10.1111/apha.12404 This article is protected by copyright. All rights reserved.

Accepted Article

Abstract AIM: To investigate how suppression of endogenous testosterone during an 8 week strength training period influences the activity of satellite cells and myonuclei. METHODS: Twenty-two moderately trained young men participated in this randomized, placebo-controlled, and double-blinded intervention study. The participants were randomized to treatment with a GnRH-analogue, goserelin (n=12), which suppresses testosterone or placebo (n=10) for 12 weeks. The strength training period of 8 weeks started after 4 weeks of treatment and included exercises for all major muscles. Biopsies were obtained from the midportion of the vastus lateralis muscle. RESULTS: Testosterone resting level in goserelin was 10-20 times lower compared with placebo and the training-induced increase in the level of testosterone was abolished in goserelin. Training increased satellite cells number in type II fibers by 20 % in placebo and by 52 % in goserelin (p

The activity of satellite cells and myonuclei following 8 weeks of strength training in young men with suppressed testosterone levels.

To investigate how suppression of endogenous testosterone during an 8-week strength training period influences the activity of satellite cells and myo...
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