HHS Public Access Author manuscript Author Manuscript
Ann Vasc Surg. Author manuscript; available in PMC 2017 August 01. Published in final edited form as: Ann Vasc Surg. 2016 August ; 35: 111–120. doi:10.1016/j.avsg.2016.02.010.
The Associations Between Peripheral Artery Disease (PAD) and Physical Outcome Measures in Men and Women with Chronic Kidney Disease (CKD)
Author Manuscript
Grace J. Wang, MD1, Pamela A. Shaw, PhD2, Raymond R. Townsend, MD3, Amanda H. Anderson, PhD, MPH2, Dawei Xie, PhD2, Xue Wang, MS2, Lisa C. Nessel, MSS2, Emile R. Mohler, MD3, Stephen M. Sozio, MD4, Bernard G. Jaar, MD4, Jing Chen, MD5, Jackson Wright, MD, PhD6, Jonathan J. Taliercio, DO7, Akinlolu Ojo, MD, PhD8, Ana C. Ricardo, MD, MPH, MS9, Eva Lustigova, MD10, Ronald M. Fairman, MD1, Harold I. Feldman, MD, MSCE2, Bonnie Ky, MD, MSCE3, and the CRIC Study Investigators11 1Department
of Surgery, 3400 Spruce Street, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA 2Department
of Biostatistics and Epidemiology, 423 Guardian Drive, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3Department
of Medicine, 3400 Civic Center Boulevard, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
4Department
of Medicine, 4940 Eastern Ave, Johns Hopkins Medical Center, Baltimore, MD
Author Manuscript
21224, USA 5Department
of Medicine, 1415 Tulane Ave, Tulane University School of Medicine, New Orleans, LA 70112, USA 6Department
of Medicine, 11100 Euclid Ave, Case Western Reserve University, Cleveland, OH
44106, USA 7Department
of Nephrology and Hypertension, 9500 Euclid Ave, Cleveland Clinic, Cleveland, OH
44195, USA 8Department
of Medicine, 1500 E. Medical Center Drive, University of Michigan School of Medicine, Ann Arbor, MI 48109-5364, USA
9Department
Author Manuscript
of Medicine, 1740 W Taylor Street, University of Illinois College of Medicine, Chicago, IL 60612, USA
10Tulane
University Health Science Center, 1440 Canal Street, New Orleans, LA 70112, USA
Abstract
*
Correspondence to: Dr. Grace J. Wang, Department of Surgery, 4 Silverstein, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, [email protected], Phone: 215-662-2069, Fax: 215-614-0463. 11The CRIC Study Investigators include: Lawrence J. Appel, Alan S. Go, Jiang He, John W. Kusek, James P. Lash, and Mahboob Rahman
Wang et al.
Page 2
Author Manuscript
Background—Peripheral artery disease (PAD) is highly prevalent and associated with significant morbidity and mortality, but sex-based differences are incompletely understood. We sought to define the associations between PAD and physical outcome measures, and to determine if these associations differed by sex in the Chronic Renal Insufficiency Cohort (CRIC). Methods—Among 3,543 participants, we assessed the cross-sectional relationship between PAD severity defined by ankle brachial index (ABI) and 1) physical activity (MET-hours/week) 2) walking pace (slow vs medium/fast) and 3) physical function (12-item Short Form Health Survey [SF-12]).
Author Manuscript
Results—In a multivariable linear regression model, PAD severity was not associated with physical activity defined by total MET-hours/week in men or women (P=0.432). However, PAD severity was significantly associated with walking activity (P=0.037), although this relationship did not differ by sex (P=0.130). Similarly, PAD severity was significantly associated with walking pace (P
Ann Vasc Surg. Author manuscript; available in PMC 2017 August 01. Published in final edited form as: Ann Vasc Surg. 2016 August ; 35: 111–120. doi:10.1016/j.avsg.2016.02.010.
The Associations Between Peripheral Artery Disease (PAD) and Physical Outcome Measures in Men and Women with Chronic Kidney Disease (CKD)
Author Manuscript
Grace J. Wang, MD1, Pamela A. Shaw, PhD2, Raymond R. Townsend, MD3, Amanda H. Anderson, PhD, MPH2, Dawei Xie, PhD2, Xue Wang, MS2, Lisa C. Nessel, MSS2, Emile R. Mohler, MD3, Stephen M. Sozio, MD4, Bernard G. Jaar, MD4, Jing Chen, MD5, Jackson Wright, MD, PhD6, Jonathan J. Taliercio, DO7, Akinlolu Ojo, MD, PhD8, Ana C. Ricardo, MD, MPH, MS9, Eva Lustigova, MD10, Ronald M. Fairman, MD1, Harold I. Feldman, MD, MSCE2, Bonnie Ky, MD, MSCE3, and the CRIC Study Investigators11 1Department
of Surgery, 3400 Spruce Street, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104, USA 2Department
of Biostatistics and Epidemiology, 423 Guardian Drive, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
3Department
of Medicine, 3400 Civic Center Boulevard, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
4Department
of Medicine, 4940 Eastern Ave, Johns Hopkins Medical Center, Baltimore, MD
Author Manuscript
21224, USA 5Department
of Medicine, 1415 Tulane Ave, Tulane University School of Medicine, New Orleans, LA 70112, USA 6Department
of Medicine, 11100 Euclid Ave, Case Western Reserve University, Cleveland, OH
44106, USA 7Department
of Nephrology and Hypertension, 9500 Euclid Ave, Cleveland Clinic, Cleveland, OH
44195, USA 8Department
of Medicine, 1500 E. Medical Center Drive, University of Michigan School of Medicine, Ann Arbor, MI 48109-5364, USA
9Department
Author Manuscript
of Medicine, 1740 W Taylor Street, University of Illinois College of Medicine, Chicago, IL 60612, USA
10Tulane
University Health Science Center, 1440 Canal Street, New Orleans, LA 70112, USA
Abstract
*
Correspondence to: Dr. Grace J. Wang, Department of Surgery, 4 Silverstein, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, [email protected], Phone: 215-662-2069, Fax: 215-614-0463. 11The CRIC Study Investigators include: Lawrence J. Appel, Alan S. Go, Jiang He, John W. Kusek, James P. Lash, and Mahboob Rahman
Wang et al.
Page 2
Author Manuscript
Background—Peripheral artery disease (PAD) is highly prevalent and associated with significant morbidity and mortality, but sex-based differences are incompletely understood. We sought to define the associations between PAD and physical outcome measures, and to determine if these associations differed by sex in the Chronic Renal Insufficiency Cohort (CRIC). Methods—Among 3,543 participants, we assessed the cross-sectional relationship between PAD severity defined by ankle brachial index (ABI) and 1) physical activity (MET-hours/week) 2) walking pace (slow vs medium/fast) and 3) physical function (12-item Short Form Health Survey [SF-12]).
Author Manuscript
Results—In a multivariable linear regression model, PAD severity was not associated with physical activity defined by total MET-hours/week in men or women (P=0.432). However, PAD severity was significantly associated with walking activity (P=0.037), although this relationship did not differ by sex (P=0.130). Similarly, PAD severity was significantly associated with walking pace (P
