OBES SURG DOI 10.1007/s11695-014-1235-9
ORIGINAL CONTRIBUTIONS
The Diagnostic Accuracy of Transient Elastography for the Diagnosis of Liver Fibrosis in Bariatric Surgery Candidates with Suspected NAFLD Sylvie Naveau & Karima Lamouri & Guillaume Pourcher & Micheline Njiké-Nakseu & Stefano Ferretti & Rodi Courie & Hadrien Tranchart & Mariana Ghinoiu & Axel Balian & Sophie Prévot & Gabriel Perlemuter & Ibrahim Dagher
# Springer Science+Business Media New York 2014
Abstract Background Severe obesity and metabolic syndrome have been implicated in the development of nonalcoholic fatty liver disease (NAFLD). We evaluated the diagnostic value of liver stiffness measurement (LSM), by transient elastography (FibroScan®) in bariatric surgery candidates with suspected NAFLD. Methods A total of 100 prospectively included consecutive severely obese subjects underwent bariatric surgery with liver needle biopsy. LSM was performed in the 15 days preceding liver biopsy. Results According to Kleiner’s classification, 28 patients had no fibrosis, 50 had stage F1 fibrosis, 13 had stage F2 fibrosis, S. Naveau (*) : K. Lamouri : M. Njiké-Nakseu : R. Courie : M. Ghinoiu : A. Balian : G. Perlemuter Service d’Hépato-gastroentérologie et Nutrition, AP-HP, Hôpital Antoine Béclère, 157 Rue de la Porte de Trivaux, Clamart 92140, France e-mail: [email protected] K. Lamouri e-mail: [email protected] M. Njiké-Nakseu e-mail: [email protected] R. Courie e-mail: [email protected] M. Ghinoiu e-mail: [email protected] A. Balian e-mail: [email protected] G. Perlemuter e-mail: [email protected] S. Naveau : M. Ghinoiu : S. Prévot : G. Perlemuter : I. Dagher Faculté de médecine Paris-Sud, Univ. Paris-Sud, 63 Rue Gabriel Péri, Le Kremlin-Bicêtre 94270, France
and nine had stage F3 fibrosis. LSMs were higher in patients with fibrosis stage F ≥2, than in patients with a fibrosis stage below F2 (p
ORIGINAL CONTRIBUTIONS
The Diagnostic Accuracy of Transient Elastography for the Diagnosis of Liver Fibrosis in Bariatric Surgery Candidates with Suspected NAFLD Sylvie Naveau & Karima Lamouri & Guillaume Pourcher & Micheline Njiké-Nakseu & Stefano Ferretti & Rodi Courie & Hadrien Tranchart & Mariana Ghinoiu & Axel Balian & Sophie Prévot & Gabriel Perlemuter & Ibrahim Dagher
# Springer Science+Business Media New York 2014
Abstract Background Severe obesity and metabolic syndrome have been implicated in the development of nonalcoholic fatty liver disease (NAFLD). We evaluated the diagnostic value of liver stiffness measurement (LSM), by transient elastography (FibroScan®) in bariatric surgery candidates with suspected NAFLD. Methods A total of 100 prospectively included consecutive severely obese subjects underwent bariatric surgery with liver needle biopsy. LSM was performed in the 15 days preceding liver biopsy. Results According to Kleiner’s classification, 28 patients had no fibrosis, 50 had stage F1 fibrosis, 13 had stage F2 fibrosis, S. Naveau (*) : K. Lamouri : M. Njiké-Nakseu : R. Courie : M. Ghinoiu : A. Balian : G. Perlemuter Service d’Hépato-gastroentérologie et Nutrition, AP-HP, Hôpital Antoine Béclère, 157 Rue de la Porte de Trivaux, Clamart 92140, France e-mail: [email protected] K. Lamouri e-mail: [email protected] M. Njiké-Nakseu e-mail: [email protected] R. Courie e-mail: [email protected] M. Ghinoiu e-mail: [email protected] A. Balian e-mail: [email protected] G. Perlemuter e-mail: [email protected] S. Naveau : M. Ghinoiu : S. Prévot : G. Perlemuter : I. Dagher Faculté de médecine Paris-Sud, Univ. Paris-Sud, 63 Rue Gabriel Péri, Le Kremlin-Bicêtre 94270, France
and nine had stage F3 fibrosis. LSMs were higher in patients with fibrosis stage F ≥2, than in patients with a fibrosis stage below F2 (p
