HHS Public Access Author manuscript Author Manuscript
Shock. Author manuscript; available in PMC 2017 September 01. Published in final edited form as: Shock. 2016 September ; 46(3 Suppl 1): 74–82. doi:10.1097/SHK.0000000000000653.
THE EFFECT OF PASSIVE HEAT STRESS AND EXERCISEINDUCED DEHYDRATION ON THE COMPENSATORY RESERVE DURING SIMULATED HEMORRHAGE Daniel Gagnon*, Zachary J. Schlader†, Amy Adams*, Eric Rivas‡, Jane Mulligan§, Gregory Z. Grudic§, Victor A. Convertino‖, Jeffrey T. Howard‖, and Craig G. Crandall*
Author Manuscript
*Institute
for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and University of Texas Southwestern Medical Center, Dallas, Texas †Department
of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, New York
‡Institute
for Clinical and Translational Science and Department of Pediatrics, University of California, Irvine, California §Flashback ‖US
Technologies Inc., Boulder, Colorado
Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas
Abstract Author Manuscript Author Manuscript
Compensatory reserve represents the proportion of physiological responses engaged to compensate for reductions in central blood volume before the onset of decompensation. We hypothesized that compensatory reserve would be reduced by hyperthermia and exercise-induced dehydration, conditions often encountered on the battlefield. Twenty healthy males volunteered for two separate protocols during which they underwent lower-body negative pressure (LBNP) to hemodynamic decompensation (systolic blood pressure
Shock. Author manuscript; available in PMC 2017 September 01. Published in final edited form as: Shock. 2016 September ; 46(3 Suppl 1): 74–82. doi:10.1097/SHK.0000000000000653.
THE EFFECT OF PASSIVE HEAT STRESS AND EXERCISEINDUCED DEHYDRATION ON THE COMPENSATORY RESERVE DURING SIMULATED HEMORRHAGE Daniel Gagnon*, Zachary J. Schlader†, Amy Adams*, Eric Rivas‡, Jane Mulligan§, Gregory Z. Grudic§, Victor A. Convertino‖, Jeffrey T. Howard‖, and Craig G. Crandall*
Author Manuscript
*Institute
for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and University of Texas Southwestern Medical Center, Dallas, Texas †Department
of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, New York
‡Institute
for Clinical and Translational Science and Department of Pediatrics, University of California, Irvine, California §Flashback ‖US
Technologies Inc., Boulder, Colorado
Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas
Abstract Author Manuscript Author Manuscript
Compensatory reserve represents the proportion of physiological responses engaged to compensate for reductions in central blood volume before the onset of decompensation. We hypothesized that compensatory reserve would be reduced by hyperthermia and exercise-induced dehydration, conditions often encountered on the battlefield. Twenty healthy males volunteered for two separate protocols during which they underwent lower-body negative pressure (LBNP) to hemodynamic decompensation (systolic blood pressure
