Ahmad et al. Trials (2015) 16:129 DOI 10.1186/s13063-015-0654-9
TRIALS
STUDY PROTOCOL
Open Access
The effect of postpartum vitamin A supplementation on breast milk immune regulators and infant immune functions: study protocol of a randomized, controlled trial Shaikh Meshbahuddin Ahmad1*, Md Iqbal Hossain2, Peter Bergman3, Yearul Kabir4 and Rubhana Raqib1
Abstract Background: Because of limited impact on infant morbidity, mortality, and vitamin A status, the new guideline of the World Health Organization (WHO) does not recommend postpartum vitamin A supplementation (VAS) as a public health intervention in developing countries. However, breast milk contains numerous immune-protective components that are important for infant immune development, and several of these components are regulated by vitamin A. Methods/design: Postpartum women are being enrolled within 3 days (d) of delivery at a maternity clinic located in a slum area of Dhaka city and randomized to one of four postpartum VAS regimens (32/group, total 128). The regimens are as follows: Group 1: 200,000 IU VAS at
TRIALS
STUDY PROTOCOL
Open Access
The effect of postpartum vitamin A supplementation on breast milk immune regulators and infant immune functions: study protocol of a randomized, controlled trial Shaikh Meshbahuddin Ahmad1*, Md Iqbal Hossain2, Peter Bergman3, Yearul Kabir4 and Rubhana Raqib1
Abstract Background: Because of limited impact on infant morbidity, mortality, and vitamin A status, the new guideline of the World Health Organization (WHO) does not recommend postpartum vitamin A supplementation (VAS) as a public health intervention in developing countries. However, breast milk contains numerous immune-protective components that are important for infant immune development, and several of these components are regulated by vitamin A. Methods/design: Postpartum women are being enrolled within 3 days (d) of delivery at a maternity clinic located in a slum area of Dhaka city and randomized to one of four postpartum VAS regimens (32/group, total 128). The regimens are as follows: Group 1: 200,000 IU VAS at
