Graefes Arch Clin Exp Ophthalmol DOI 10.1007/s00417-014-2599-1
CORNEA
The efficacy of autologous serum eye drops for severe dry eye syndrome: a randomized double-blind crossover study Ali Riza Cenk Celebi & Cemalettin Ulusoy & G. Ertugrul Mirza
Received: 2 October 2013 / Revised: 19 January 2014 / Accepted: 4 February 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservativefree artificial tears (PFAT). Methods This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer’s Test, and OXFORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P 40 [5]. OSDI is a reliable and valid test for quantifying the severity of dry eye symptoms [19]. Patients with an active ocular infection or any other inflammation not associated with dry eye, a severe associated ocular allergy, eyelid or eyelash abnormality, current contact lens use, history of refractive surgery, associated glaucoma, and current use of any type of topical eye drops other than dry eye medications, any known graft-versus host disease, known severe anemia (hemoglobin
CORNEA
The efficacy of autologous serum eye drops for severe dry eye syndrome: a randomized double-blind crossover study Ali Riza Cenk Celebi & Cemalettin Ulusoy & G. Ertugrul Mirza
Received: 2 October 2013 / Revised: 19 January 2014 / Accepted: 4 February 2014 # Springer-Verlag Berlin Heidelberg 2014
Abstract Background To evaluate the efficacy of autologous serum (AS) eye drops for the symptomatic relief of severe dry eye syndrome (DES), as compared to conventional preservativefree artificial tears (PFAT). Methods This prospective double-blind randomized crossover study used the Ocular Surface Disease Index (OSDI), tear film break-up time (TBUT), Schirmer’s Test, and OXFORD Scale at baseline and after each of two 1-month treatment periods to measure the effect of 20 % diluted AS eye drops vs. PFAT in 20 consecutive severe DES patients that were refractory to conventional treatment. Results The study included 20 (18 female and two male) severe DES patients (40 eyes). Significantly higher TBUT (P 40 [5]. OSDI is a reliable and valid test for quantifying the severity of dry eye symptoms [19]. Patients with an active ocular infection or any other inflammation not associated with dry eye, a severe associated ocular allergy, eyelid or eyelash abnormality, current contact lens use, history of refractive surgery, associated glaucoma, and current use of any type of topical eye drops other than dry eye medications, any known graft-versus host disease, known severe anemia (hemoglobin
